Adrian Acuna-Ruiz
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Explore the profile of Adrian Acuna-Ruiz including associated specialties, affiliations and a list of published articles.
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9
Citations
67
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Recent Articles
1.
Krishnamoorthy G, Glover A, Untch B, Sigcha-Coello N, Xu B, Vukel D, et al.
J Exp Med
. 2025 Feb;
222(5).
PMID: 39992626
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function RBM10 mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by RBM10 loss showed pro-migratory and RHO/RAC...
2.
Li L, Jiang W, Wei W, Krishnamoorthy G, Hu P, Chen M, et al.
Sci Data
. 2024 Dec;
11(1):1448.
PMID: 39732735
Thyroid nodules are a common endocrine condition with an increasing incidence over the decades. Data-independent acquisition has been widely utilized in discovery proteomics to identify disease biomarkers and therapeutic targets....
3.
Krishnamoorthy G, Glover A, Untch B, Sigcha-Coello N, Xu B, Vukel D, et al.
bioRxiv
. 2024 Jul;
PMID: 39026820
RBM10 modulates transcriptome-wide cassette exon splicing. Loss-of-function mutations are enriched in thyroid cancers with distant metastases. Analysis of transcriptomes and genes mis-spliced by RBM10 loss showed pro-migratory and RHO/RAC signaling...
4.
Garcia-Rendueles M, Krishnamoorthy G, Saqcena M, Acuna-Ruiz A, Revilla G, de Stanchina E, et al.
Mol Cancer
. 2022 Dec;
21(1):213.
PMID: 36476495
Background: Inactivation of the Hippo pathway promotes Yap nuclear translocation, enabling execution of a transcriptional program that induces tissue growth. Genetic lesions of Hippo intermediates only identify a minority of...
5.
Zaballos M, Acuna-Ruiz A, Morante M, Riesco-Eizaguirre G, Crespo P, Santisteban P
Cell Mol Life Sci
. 2022 Sep;
79(9):504.
PMID: 36056964
Background: RAS-to-ERK signaling is crucial for the onset and progression of advanced thyroid carcinoma, and blocking ERK dimerization provides a therapeutic benefit in several human carcinomas. Here we analyzed the...
6.
Ramirez-Moya J, Wert-Lamas L, Acuna-Ruiz A, Fletcher A, Wert-Carvajal C, McCabe C, et al.
Sci Rep
. 2022 May;
12(1):7706.
PMID: 35562181
Thyroid cancer is the most common primary endocrine malignancy in adults and its incidence is rapidly increasing. Long non-coding RNAs (lncRNAs), generally defined as RNA molecules longer than 200 nucleotides...
7.
Acuna-Ruiz A, Carrasco-Lopez C, Santisteban P
Best Pract Res Clin Endocrinol Metab
. 2022 Apr;
37(1):101656.
PMID: 35461756
Thyroid cancer is the most common malignancy of the endocrine system, and its incidence has been steadily increasing. Advances in sequencing have allowed analysis of the entire cancer genome, and...
8.
Ramirez-Moya J, Wert-Lamas L, Acuna-Ruiz A, Zaballos M, Santisteban P
J Vis Exp
. 2019 Sep;
(150).
PMID: 31498304
MicroRNAs (miRNAs) are important regulators of gene expression through their ability to destabilize mRNA and inhibit translation of target mRNAs. An ever-increasing number of studies have identified miRNAs as potential...
9.
Zaballos M, Acuna-Ruiz A, Morante M, Crespo P, Santisteban P
Endocr Relat Cancer
. 2019 Apr;
26(6):R319-R344.
PMID: 30978703
Thyroid cancer is mostly an ERK-driven carcinoma, as up to 70% of thyroid carcinomas are caused by mutations that activate the RAS/ERK mitogenic signaling pathway. The incidence of thyroid cancer...
10.
Ruiz-Carpio V, Sandoval P, Aguilera A, Albar-Vizcaino P, Perez-Lozano M, Gonzalez-Mateo G, et al.
Sci Rep
. 2017 Mar;
7:44941.
PMID: 28327551
Peritoneal dialysis (PD) is an effective renal replacement therapy, but a significant proportion of patients suffer PD-related complications, which limit the treatment duration. Mesothelial-to-mesenchymal transition (MMT) contributes to the PD-related...