Adeline Martz
Overview
Explore the profile of Adeline Martz including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
273
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0
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Recent Articles
1.
Peralta F, Balcon M, Martz A, Biljali D, Cevoli F, Arnould B, et al.
Nat Commun
. 2023 Mar;
14(1):1269.
PMID: 36882406
PIEZO proteins are unusually large, mechanically-activated trimeric ion channels. The central pore features structural similarities with the pore of other trimeric ion channels, including purinergic P2X receptors, for which optical...
2.
Dunning K, Martz A, Peralta F, Cevoli F, Boue-Grabot E, Compan V, et al.
Int J Mol Sci
. 2021 Jul;
22(12).
PMID: 34207150
P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the...
3.
Harkat M, Peverini L, Cerdan A, Dunning K, Beudez J, Martz A, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(19):E3786-E3795.
PMID: 28442564
Pore dilation is thought to be a hallmark of purinergic P2X receptors. The most commonly held view of this unusual process posits that under prolonged ATP exposure the ion pore...
4.
Habermacher C, Martz A, Calimet N, Lemoine D, Peverini L, Specht A, et al.
Elife
. 2016 Jan;
5:e11050.
PMID: 26808983
P2X receptors function by opening a transmembrane pore in response to extracellular ATP. Recent crystal structures solved in apo and ATP-bound states revealed molecular motions of the extracellular domain following...
5.
Lemoine D, Habermacher C, Martz A, Mery P, Bouquier N, Diverchy F, et al.
Proc Natl Acad Sci U S A
. 2013 Dec;
110(51):20813-8.
PMID: 24297890
The powerful optogenetic pharmacology method allows the optical control of neuronal activity by photoswitchable ligands tethered to channels and receptors. However, this approach is technically demanding, as it requires the...
6.
Jiang R, Taly A, Lemoine D, Martz A, Specht A, Grutter T
Channels (Austin)
. 2012 Sep;
6(5):398-402.
PMID: 22992569
The molecular mechanism underlying channel opening in response to agonist binding remains a challenging issue in neuroscience. In this regard, many efforts have been recently undertaken in ATP-gated P2X receptors....
7.
Jiang R, Taly A, Lemoine D, Martz A, Cunrath O, Grutter T
EMBO J
. 2012 Apr;
31(9):2134-43.
PMID: 22473210
The opening of ligand-gated ion channels in response to agonist binding is a fundamental process in biology. In ATP-gated P2X receptors, little is known about the molecular events that couple...
8.
Jiang R, Lemoine D, Martz A, Taly A, Gonin S, Prado de Carvalho L, et al.
Proc Natl Acad Sci U S A
. 2011 May;
108(22):9066-71.
PMID: 21576497
ATP-gated P2X receptors are trimeric ion channels, as recently confirmed by X-ray crystallography. However, the structure was solved without ATP and even though extracellular intersubunit cavities surrounded by conserved amino...
9.
Jiang R, Miyamoto A, Martz A, Specht A, Ishibashi H, Kueny-Stotz M, et al.
Br J Pharmacol
. 2010 Dec;
162(6):1326-39.
PMID: 21133889
Background And Purpose: Flavonoids, important plant pigments, have been shown to allosterically modulate brain GABA(A) receptors (GABA(A)Rs). We previously reported that trans-6,4'-dimethoxyretrochalcone (Rc-OMe), a hydrolytic derivative of the corresponding flavylium...
10.
Jiang R, Martz A, Gonin S, Taly A, Prado de Carvalho L, Grutter T
J Biol Chem
. 2010 Mar;
285(21):15805-15.
PMID: 20308075
The recent crystal structure of the ATP-gated P2X4 receptor revealed a static view of its architecture, but the molecular mechanisms underlying the P2X channels activation are still unknown. By using...