Adele Cooney
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Explore the profile of Adele Cooney including associated specialties, affiliations and a list of published articles.
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7
Citations
279
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Recent Articles
1.
Goldstein D, Sullivan P, Cooney A, Jinsmaa Y, Kopin I, Sharabi Y
J Neurochem
. 2015 Feb;
133(1):14-25.
PMID: 25645689
Repeated systemic administration of the mitochondrial complex I inhibitor rotenone produces a rodent model of Parkinson's disease (PD). Mechanisms of relatively selective rotenone-induced damage to nigrostriatal dopaminergic neurons remain incompletely...
2.
Jinsmaa Y, Cooney A, Sullivan P, Sharabi Y, Goldstein D
Neurosci Lett
. 2015 Feb;
590:134-7.
PMID: 25637699
In Parkinson's disease (PD) alpha-synuclein oligomers are thought to be pathogenic, and 3,4-dihydroxyphenylacetaldehyde (DOPAL), an obligate aldehyde intermediate in neuronal dopamine metabolism, potently oligomerizes alpha-synuclein. PD involves alpha-synuclein deposition in...
3.
Casida J, Ford B, Jinsmaa Y, Sullivan P, Cooney A, Goldstein D
Chem Res Toxicol
. 2014 Jul;
27(8):1359-61.
PMID: 25045800
The dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is detoxified mainly by aldehyde dehydrogenase (ALDH). We find that the fungicide benomyl potently and rapidly inhibits ALDH and builds up DOPAL in vivo in...
4.
Jinsmaa Y, Sullivan P, Gross D, Cooney A, Sharabi Y, Goldstein D
Neurosci Lett
. 2014 Mar;
569:27-32.
PMID: 24670480
Parkinson disease (PD) features profound striatal dopamine depletion and Lewy bodies containing abundant precipitated alpha-synuclein. Mechanisms linking alpha-synucleinopathy with the death of dopamine neurons remain incompletely understood. One such link...
5.
Goldstein D, Sullivan P, Cooney A, Jinsmaa Y, Sullivan R, Gross D, et al.
J Neurochem
. 2012 Aug;
123(6):932-43.
PMID: 22906103
Parkinson's disease entails profound loss of nigrostriatal dopaminergic terminals, decreased vesicular uptake of intraneuronal catecholamines, and relatively increased putamen tissue concentrations of the toxic dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde (DOPAL). The objective...
6.
Raychowdhury M, Gonzalez-Perrett S, Montalbetti N, Timpanaro G, Chasan B, Goldmann W, et al.
Hum Mol Genet
. 2004 Jan;
13(6):617-27.
PMID: 14749347
Mucolipidosis type IV (MLIV) is an autosomal recessive neurogenetic disorder characterized by developmental abnormalities of the brain and impaired neurological, ophthalmologic and gastric function. Large vacuoles accumulate in various types...
7.
Neufeld E, Stonik J, Demosky Jr S, Knapper C, Combs C, Cooney A, et al.
J Biol Chem
. 2004 Jan;
279(15):15571-8.
PMID: 14747463
We have previously established that the ABCA1 transporter, which plays a critical role in the lipidation of extracellular apolipoprotein acceptors, traffics between late endocytic vesicles and the cell surface (Neufeld,...