Adam T Comstock
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Explore the profile of Adam T Comstock including associated specialties, affiliations and a list of published articles.
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22
Citations
929
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Recent Articles
1.
Han M, Barreto T, Martinez F, Comstock A, Sajjan U
BMJ Open Respir Res
. 2020 Feb;
7(1).
PMID: 32071149
Introduction: Quercetin is a plant flavonoid and has potent antioxidant and anti-inflammatory properties. In a preclinical model of chronic obstructive pulmonary disease (COPD), quercetin reduced markers of both oxidative stress...
2.
Lewis T, Metitiri E, Mentz G, Ren X, Carpenter A, Goldsmith A, et al.
Respir Res
. 2018 Nov;
19(1):228.
PMID: 30463560
Background: Few longitudinal studies examine inflammation and lung function in asthma. We sought to determine the cytokines that reduce airflow, and the influence of respiratory viral infections on these relationships....
3.
Lewis T, Metitiri E, Mentz G, Ren X, Goldsmith A, Eder B, et al.
Ann Allergy Asthma Immunol
. 2018 Nov;
122(2):175-183.e2.
PMID: 30385348
Background: Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on children with asthma in the community, particularly in the high-risk urban environment,...
4.
Jing Y, Gimenes J, Mishra R, Pham D, Comstock A, Yu D, et al.
Thorax
. 2018 Jul;
74(1):18-32.
PMID: 29991510
Rationale: Goblet cell hyperplasia (GCH) is one of the cardinal features of chronic obstructive pulmonary disease (COPD) and contributes to airways obstruction. Rhinovirus (RV), which causes acute exacerbations in patients...
5.
Farazuddin M, Mishra R, Jing Y, Srivastava V, Comstock A, Sajjan U
PLoS One
. 2018 Jul;
13(7):e0199612.
PMID: 29975735
Acute exacerbations are the major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). Rhinovirus, which causes acute exacerbations may also accelerate progression of lung disease...
6.
Ganesan S, Pham D, Jing Y, Farazuddin M, Hudy M, Unger B, et al.
J Immunol
. 2016 Aug;
197(6):2409-20.
PMID: 27503209
Airway epithelial cells are the major target for rhinovirus (RV) infection and express proinflammatory chemokines and antiviral cytokines that play a role in innate immunity. Previously, we demonstrated that RV...
7.
Faris A, Ganesan S, Chattoraj A, Chattoraj S, Comstock A, Unger B, et al.
Am J Respir Cell Mol Biol
. 2016 Apr;
55(4):487-499.
PMID: 27119973
Rhinovirus (RV), which causes exacerbation in patients with chronic airway diseases, readily infects injured airway epithelium and has been reported to delay wound closure. In this study, we examined the...
8.
Balijepalli A, Comstock A, Wang X, Jensen G, Hershenson M, Zacharek M, et al.
Mol Pharm
. 2015 May;
12(7):2396-405.
PMID: 25978582
Nitric oxide (NO) is a key immune defense agent that is produced from l-arginine in the airways by leukocytes and airway epithelial cells, primarily via inducible nitric oxide synthase (iNOS)....
9.
Hong J, Chung Y, Steenrod J, Chen Q, Lei J, Comstock A, et al.
Respir Res
. 2014 Jun;
15:63.
PMID: 24907978
Background: The mechanisms by which viruses cause asthma exacerbations are not precisely known. Previously, we showed that, in ovalbumin (OVA)-sensitized and -challenged mice with allergic airway inflammation, rhinovirus (RV) infection...
10.
Ganesan S, Comstock A, Sajjan U
Tissue Barriers
. 2014 Mar;
1(4):e24997.
PMID: 24665407
Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary escalator, intercellular apical junctional complexes which regulate paracellular permeability and antimicrobial peptides secreted by the airway epithelial cells...