Adam T Comstock
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Explore the profile of Adam T Comstock including associated specialties, affiliations and a list of published articles.
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22
Citations
929
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Recent Articles
11.
Ganesan S, Comstock A, Kinker B, Mancuso P, Beck J, Sajjan U
Respir Res
. 2014 Feb;
15:11.
PMID: 24495712
Background: Cigarette smoke (CS) is the major etiologic factor of chronic obstructive pulmonary disease (COPD). CS-exposed mice develop emphysema and mild pulmonary inflammation but no airway obstruction, which is also...
12.
Unger B, Ganesan S, Comstock A, Faris A, Hershenson M, Sajjan U
J Virol
. 2014 Jan;
88(7):3705-18.
PMID: 24429360
Unlabelled: Barrier dysfunction of airway epithelium may increase the risk for acquiring secondary infections or allergen sensitization. Both rhinovirus (RV) and polyinosinic-polycytidilic acid [poly(I·C)], a double-stranded RNA (dsRNA) mimetic, cause...
13.
Ganesan S, Unger B, Comstock A, Angel K, Mancuso P, Martinez F, et al.
Thorax
. 2012 Oct;
68(2):131-41.
PMID: 23099361
Background: Decreased activity of forkhead transcription factor class O (FoxO)3A, a negative regulator of NF-κB-mediated chemokine expression, is implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Previously, we...
14.
Unger B, Faris A, Ganesan S, Comstock A, Hershenson M, Sajjan U
PLoS Pathog
. 2012 Oct;
8(10):e1002969.
PMID: 23055935
Bacterial infections following rhinovirus (RV), a common cold virus, are well documented, but pathogenic mechanisms are poorly understood. We developed animal and cell culture models to examine the effects of...
15.
Ganesan S, Faris A, Comstock A, Wang Q, Nanua S, Hershenson M, et al.
Antiviral Res
. 2012 Apr;
94(3):258-71.
PMID: 22465313
Rhinovirus (RV), which is responsible for the majority of common colds, also causes exacerbations in patients with asthma and chronic obstructive pulmonary disease. So far, there are no drugs available...
16.
Ganesan S, Faris A, Comstock A, Sonstein J, Curtis J, Sajjan U
Am J Pathol
. 2011 Nov;
180(1):61-72.
PMID: 22079429
Nontypeable Haemophilus influenzae (NTHi) is an important bacterial pathogen associated with lower respiratory tract colonization and with acute exacerbations and disease progression in chronic obstructive pulmonary disease (COPD). Why the...
17.
Goldberg J, Ganesan S, Comstock A, Zhao Y, Sajjan U
PLoS One
. 2011 Aug;
6(7):e22435.
PMID: 21811611
Background: Infection by Burkholderia cenocepacia in cystic fibrosis (CF) patients is associated with poor clinical prognosis. Previously, we demonstrated that one of the highly transmissible strains, BC7, expresses cable pili...
18.
Comstock A, Ganesan S, Chattoraj A, Faris A, Margolis B, Hershenson M, et al.
J Virol
. 2011 Apr;
85(13):6795-808.
PMID: 21507984
Previously, we showed that rhinovirus (RV), which is responsible for the majority of common colds, disrupts airway epithelial barrier function, as evidenced by reduced transepithelial resistance (R(T)), dissociation of zona...
19.
Chattoraj S, Ganesan S, Jones A, Helm J, Comstock A, Bright-Thomas R, et al.
Thorax
. 2011 Feb;
66(4):333-9.
PMID: 21289024
Background: Intermittent viral exacerbations in patients with cystic fibrosis (CF) with chronic Pseudomonas aeruginosa (PA) infection are associated with increased bacterial load. A few clinical studies suggest that rhinoviruses (RV)...
20.
Ganesan S, Faris A, Comstock A, Chattoraj S, Chattoraj A, Burgess J, et al.
Respir Res
. 2010 Oct;
11:131.
PMID: 20920189
Background: Chronic obstructive pulmonary disease (COPD) is characterized by chronic bronchitis, emphysema and irreversible airflow limitation. These changes are thought to be due to oxidative stress and an imbalance of...