Adam R Farley
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Explore the profile of Adam R Farley including associated specialties, affiliations and a list of published articles.
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7
Citations
84
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Recent Articles
1.
Link A, Niu X, Weaver C, Jennings J, Duncan D, McAfee K, et al.
Proteomics
. 2020 Feb;
20(7):e1900177.
PMID: 32027465
To identify protein-protein interactions and phosphorylated amino acid sites in eukaryotic mRNA translation, replicate TAP-MudPIT and control experiments are performed targeting Saccharomyces cerevisiae genes previously implicated in eukaryotic mRNA translation...
2.
Farley A, Powell D, Weaver C, Jennings J, Link A
J Proteome Res
. 2011 Feb;
10(4):1481-94.
PMID: 21280672
The eukaryotic initiation factor 3 (eIF3) is an essential, highly conserved multiprotein complex that is a key component in the recruitment and assembly of the translation initiation machinery. To better...
3.
Umanah G, Huang L, Ding F, Arshava B, Farley A, Link A, et al.
J Biol Chem
. 2010 Oct;
285(50):39425-36.
PMID: 20923758
Fundamental knowledge about how G protein-coupled receptors and their ligands interact is important for understanding receptor-ligand binding and the development of new drug discovery strategies. We have used cross-linking and...
4.
Farley A, Link A
Methods Enzymol
. 2009 Nov;
463:725-63.
PMID: 19892200
Posttranslational modifications (PTMs) of proteins perform crucial roles in regulating the biology of the cell. PTMs are enzymatic, covalent chemical modifications of proteins that typically occur after the translation of...
5.
Copeland K, Anderson J, Farley A, Cox J, Tschumper G
J Phys Chem B
. 2008 Oct;
112(45):14291-5.
PMID: 18922031
To examine the effects of pi-stacking interactions between aromatic amino acid side chains and adenine bearing ligands in crystalline protein structures, 26 toluene/(N9-methyl)adenine model configurations have been constructed from protein/ligand...
6.
Boehr D, Farley A, LaRonde F, Murdock T, Wright G, Cox J
Biochemistry
. 2005 Sep;
44(37):12445-53.
PMID: 16156657
The protein-based molecular recognition of the adenine ring has implications throughout biological systems. In this paper, we discuss the adenine-binding region of an aminoglycoside antibiotic kinase [APH(3')-IIIa], which serves as...
7.
Boehr D, Farley A, Wright G, Cox J
Chem Biol
. 2002 Nov;
9(11):1209-17.
PMID: 12445771
A key contact in the active site of an aminoglycoside phosphotransferase enzyme (APH(3')-IIIa) is a pi-pi stacking interaction between Tyr42 and the adenine ring of bound nucleotides. We investigated the...