Adam Mark
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Explore the profile of Adam Mark including associated specialties, affiliations and a list of published articles.
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20
Citations
357
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Recent Articles
1.
Huang M, Mark A, Pham J, Vera K, Saravia-Butler A, Beheshti A, et al.
PLoS One
. 2024 Aug;
19(8):e0307450.
PMID: 39178184
Adenosine to inosine (A-to-I) RNA editing by ADAR1 has been implicated in maintaining self-tolerance, preventing autoimmunity, and mediating antiviral immunity. Foreign viral double-stranded RNA triggers rapid interferon response and activates...
2.
Fisch K, Rosenthal S, Mark A, Sasik R, Nasamran C, Clifford R, et al.
BMC Genomics
. 2024 Jun;
25(1):646.
PMID: 38943082
Background: Ménière's disease (MD) is a disorder of the inner ear that causes episodic bouts of severe dizziness, roaring tinnitus, and fluctuating hearing loss. To date, no targeted therapy exists....
3.
Rivera M, Zhang H, Pham J, Isquith J, Zhou Q, Balaian L, et al.
Cell Rep
. 2024 Jan;
43(2):113704.
PMID: 38265938
Leukemia-initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches. Here, we...
4.
Garcia C, Velez L, Ujagar N, Del Mundo Z, Nguyen T, Fox C, et al.
Front Endocrinol (Lausanne)
. 2024 Jan;
14:1279878.
PMID: 38260148
Introduction: Female reproductive function depends on a choreographed sequence of hormonal secretion and action, where specific stresses such as inflammation exert profound disruptions. Specifically, acute LPS-induced inflammation inhibits gonadotropin production...
5.
Qualliotine J, Nakagawa T, Rosenthal S, Sadat S, Ballesteros-Merino C, Xu G, et al.
Cancers (Basel)
. 2023 Sep;
15(17).
PMID: 37686653
HPV-associated oropharynx carcinoma (HPVOPC) tumors have a relatively low mutational burden. Elucidating the relative contributions of other tumor alterations, such as DNA methylation alterations, alternative splicing events (ASE), and copy...
6.
Rivera M, Zhang H, Pham J, Isquith J, Zhou Q, Sasik R, et al.
Res Sq
. 2023 Jul;
PMID: 37398458
Leukemia initiating cells (LICs) are regarded as the origin of leukemia relapse and therapeutic resistance. Identifying direct stemness determinants that fuel LIC self-renewal is critical for developing targeted approaches to...
7.
Baghdassarian H, Blackstone S, Clay O, Philips R, Matthiasardottir B, Nehrebecky M, et al.
N Engl J Med
. 2023 May;
388(24):2241-2252.
PMID: 37256972
Background: Disabling pansclerotic morphea (DPM) is a rare systemic inflammatory disorder, characterized by poor wound healing, fibrosis, cytopenias, hypogammaglobulinemia, and squamous-cell carcinoma. The cause is unknown, and mortality is high....
8.
van der Werf I, Mondala P, Steel S, Balaian L, Ladel L, Mason C, et al.
Cell Rep Med
. 2023 Mar;
4(3):100962.
PMID: 36889320
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel...
9.
Shoshani O, Bakker B, de Haan L, Tijhuis A, Wang Y, Kim D, et al.
Genes Dev
. 2021 Jul;
35(15-16):1093-1108.
PMID: 34266887
Abnormal numerical and structural chromosome content is frequently found in human cancer. To test the role of aneuploidy in tumor initiation and progression, we generated mice with random aneuploidies by...
10.
Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, et al.
Cell Rep
. 2021 Jan;
34(4):108670.
PMID: 33503434
Inflammation-dependent base deaminases promote therapeutic resistance in many malignancies. However, their roles in human pre-leukemia stem cell (pre-LSC) evolution to acute myeloid leukemia stem cells (LSCs) had not been elucidated....