Adam J Fletcher
Overview
Explore the profile of Adam J Fletcher including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1499
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Recent Articles
1.
Fletcher A, Mabbitt P
Front Mol Biosci
. 2023 Sep;
10:1275393.
PMID: 37681016
No abstract available.
2.
De Cesare V, Carbajo Lopez D, Mabbitt P, Fletcher A, Soetens M, Antico O, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(4).
PMID: 33479176
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are encoded by the human genome,...
3.
Mabbitt P, Loreto A, Dery M, Fletcher A, Stanley M, Pao K, et al.
Nat Chem Biol
. 2020 Aug;
16(11):1227-1236.
PMID: 32747811
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism,...
4.
Mathur S, Fletcher A, Branigan E, Hay R, Virdee S
Cell Chem Biol
. 2019 Dec;
27(1):74-82.e6.
PMID: 31859248
Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate...
5.
Mallery D, Faysal K, Kleinpeter A, Wilson M, Vaysburd M, Fletcher A, et al.
Cell Rep
. 2019 Dec;
29(12):3983-3996.e4.
PMID: 31851928
HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP) for viral production and primary cell replication. HIV-1...
6.
Fletcher A, Vaysburd M, Maslen S, Zeng J, Skehel J, Towers G, et al.
Cell Host Microbe
. 2018 Dec;
24(6):761-775.e6.
PMID: 30503508
TRIM5 is a RING domain E3 ubiquitin ligase with potent antiretroviral function. TRIM5 assembles into a hexagonal lattice on retroviral capsids, causing envelopment of the infectious core. Concomitantly, TRIM5 initiates...
7.
Dickson C, Fletcher A, Vaysburd M, Yang J, Mallery D, Zeng J, et al.
Elife
. 2018 Apr;
7.
PMID: 29667579
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but...
8.
Hudson A, Stephenson N, Li C, Trotter E, Fletcher A, Katona G, et al.
Sci Signal
. 2018 Apr;
11(526).
PMID: 29666306
A major challenge in cancer genomics is identifying "driver" mutations from the many neutral "passenger" mutations within a given tumor. To identify driver mutations that would otherwise be lost within...
9.
Fletcher A, James L
J Virol
. 2016 Mar;
90(10):4856-4859.
PMID: 26937031
TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells. Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional...
10.
Fletcher A, Mallery D, Watkinson R, Dickson C, James L
Proc Natl Acad Sci U S A
. 2015 Jul;
112(32):10014-9.
PMID: 26150489
Tripartite motif (TRIM) 21 is a cytosolic antibody receptor that neutralizes antibody-coated viruses that penetrate the cell and simultaneously activates innate immunity. Here we show that the conjugation of TRIM21...