Adam C Searleman
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Explore the profile of Adam C Searleman including associated specialties, affiliations and a list of published articles.
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26
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1201
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Recent Articles
11.
Jang H, Carl M, Ma Y, Searleman A, Jerban S, Chang E, et al.
Quant Imaging Med Surg
. 2020 Jun;
10(5):895-906.
PMID: 32489915
Background: Myelin alteration is closely associated with neurological diseases such as multiple sclerosis (MS). Unfortunately, due to myelin's extremely short T2* (~0.3 ms or shorter at 3T), it cannot be...
12.
Ma Y, Searleman A, Jang H, Wong J, Chang E, Corey-Bloom J, et al.
Radiology
. 2019 Nov;
294(2):362-374.
PMID: 31746689
Background Signal contamination from long T2 water is a major challenge in direct imaging of myelin with MRI. Nulling of the unwanted long T2 signals can be achieved with an...
13.
Guo T, Ma Y, High R, Tang Q, Wong J, Byra M, et al.
Eur J Radiol
. 2019 Oct;
121:108706.
PMID: 31655315
Purpose: Quantitative imaging methods could improve diagnosis of rotator cuff degeneration, but the capability of quantitative MR and US imaging parameters to detect alterations in collagen is unknown. The goal...
14.
Jang H, Ma Y, Searleman A, Carl M, Corey-Bloom J, Chang E, et al.
Magn Reson Med
. 2019 Sep;
83(3):950-961.
PMID: 31532032
Purpose: Direct myelin imaging can improve the characterization of myelin-related diseases such as multiple sclerosis. In this study, we explore a novel method to directly image myelin using inversion recovery-prepared...
15.
Wan L, Zhao W, Ma Y, Jerban S, Searleman A, Carl M, et al.
Magn Reson Med
. 2019 Mar;
82(1):225-236.
PMID: 30821032
Purpose: To investigate the effect of stretching sampling window on quantitative 3D ultrashort TE (UTE) imaging of cortical bone at 3 T. Methods: Ten bovine cortical bone and 17 human...
16.
Jerban S, Ma Y, Wan L, Searleman A, Jang H, Sah R, et al.
NMR Biomed
. 2018 Dec;
32(2):e4045.
PMID: 30549338
Intracortical bone porosity is a key microstructural parameter that determines bone mechanical properties. While clinical MRI visualizes the cortical bone with a signal void, ultrashort echo time (UTE) MRI can...
17.
Jang H, Lu X, Carl M, Searleman A, Jerban S, Ma Y, et al.
Magn Reson Med
. 2018 Oct;
81(3):1907-1914.
PMID: 30325058
Purpose: In this study, we explore the feasibility of a new imaging scheme for quantitative susceptibility mapping (QSM): continuous single-point imaging (CSPI), which uses a pure phase encoding strategy to...
18.
Kavuri S, Jain N, Galimi F, Cottino F, Leto S, Migliardi G, et al.
Cancer Discov
. 2015 Aug;
5(8):832-41.
PMID: 26243863
Unlabelled: The Cancer Genome Atlas project identified HER2 somatic mutations and gene amplification in 7% of patients with colorectal cancer. Introduction of the HER2 mutations S310F, L755S, V777L, V842I, and...
19.
Kumar R, Searleman A, Swamidass S, Griffith O, Bose R
Bioinformatics
. 2015 Jul;
31(22):3561-8.
PMID: 26209800
Motivation: Several tools exist to identify cancer driver genes based on somatic mutation data. However, these tools do not account for subclasses of cancer genes: oncogenes, which undergo gain-of-function events,...
20.
Takeda S, Sasagawa S, Oyama T, Searleman A, Westergard T, Cheng E, et al.
J Clin Invest
. 2015 Feb;
125(3):1203-14.
PMID: 25664857
Head morphogenesis requires complex signal relays to enable precisely coordinated proliferation, migration, and patterning. Here, we demonstrate that, during mouse head formation, taspase1-mediated (TASP1-mediated) cleavage of the general transcription factor...