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Adam C Searleman

Explore the profile of Adam C Searleman including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Murphy P, An J, Wojdyla L, Searleman A, Khurana A, Loehfelm T, et al.
J Imaging Inform Med . 2024 Nov; PMID: 39495441
Next-generation virtual/augmented reality (VR/AR) headsets may rival the desktop computer systems that are approved for clinical interpretation of radiologic images, but require validation for high-resolution low-luminance diagnoses like diverticulitis. The...
2.
Searleman A, Ma Y, Sampath S, Sampath S, Bussell R, Chang E, et al.
Front Neuroimaging . 2024 May; 3():1356713. PMID: 38783990
Purpose: To test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model. Methods: Non-aqueous myelin protons have ultrashort...
3.
Wan L, Searleman A, Ma Y, Wong J, Williams J, Murphy M, et al.
Quant Imaging Med Surg . 2023 Oct; 13(10):6942-6951. PMID: 37869338
Background: The effect of dehydration of cartilage samples and rehydration with native synovial fluid or normal saline on quantitative ultrashort echo time (UTE) biomarkers are unknown. We aimed to investigate...
4.
Lombardi A, Ma Y, Jang H, Jerban S, Tang Q, Searleman A, et al.
Int J Mol Sci . 2023 Aug; 24(15). PMID: 37569908
In the original publication, there was a mistake in Figure 1 as published [...].
5.
Lombardi A, Ma Y, Jang H, Jerban S, Tang Q, Searleman A, et al.
Int J Mol Sci . 2022 Apr; 23(8). PMID: 35457284
A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. Acidosis Chemical Exchange Saturation Transfer (acidoCEST) indirectly measures the extracellular pH through the...
6.
Wan L, Cheng X, Searleman A, Ma Y, Wong J, Meyer R, et al.
NMR Biomed . 2021 Dec; 35(5):e4664. PMID: 34904305
The objective of the current study was to investigate the feasibility of quantitative 3D ultrashort echo time (UTE)-based biomarkers in detecting proteoglycan (PG) loss and collagen degradation in human cartilage....
7.
Niizuma H, Searleman A, Takeda S, Armstrong S, Park C, Cheng E, et al.
JCI Insight . 2021 Jun; 6(15). PMID: 34156981
Taspase1, a highly conserved threonine protease encoded by TASP1, cleaves nuclear histone-modifying factors and basal transcription regulators to orchestrate diverse transcription programs. Hereditary loss-of-function mutation of TASP1 has recently been...
8.
Searleman A, Aganovic L, Santillan C
Radiol Clin North Am . 2021 May; 59(4):569-590. PMID: 34053606
Hepatic incidental findings often are seen on cross-sectional imaging examinations of the chest, spine, pelvis, or other nondedicated hepatic imaging. Radiologists are tasked with appropriately triaging, which requires further evaluation,...
9.
Ma Y, Searleman A, Jang H, Fan S, Wong J, Xue Y, et al.
NMR Biomed . 2020 Jul; 33(10):e4326. PMID: 32691472
Direct myelin imaging is promising for characterization of multiple sclerosis (MS) brains at diagnosis and in response to therapy. In this study, a 3D inversion recovery-prepared ultrashort echo time cones...
10.
Wan L, Ma Y, Yang J, Jerban S, Searleman A, Carl M, et al.
NMR Biomed . 2020 Jul; 33(10):e4376. PMID: 32667115
The purpose of this study is to investigate the effect of extending the spiral sampling window on quantitative 3D ultrashort echo time (UTE) Cones imaging of major knee joint tissues...