Adam B Robertson
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Explore the profile of Adam B Robertson including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
361
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Recent Articles
1.
Vander Zanden C, Czarny R, Ho E, Robertson A, Ho P
Nucleic Acids Res
. 2020 Feb;
48(7):3962-3974.
PMID: 32095813
Modified DNA bases functionally distinguish the taxonomic forms of life-5-methylcytosine separates prokaryotes from eukaryotes and 5-hydroxymethylcytosine (5hmC) invertebrates from vertebrates. We demonstrate here that mouse endonuclease G (mEndoG) shows specificity...
2.
Prikrylova T, Robertson J, Ferrucci F, Konorska D, Aanes H, Manaf A, et al.
Sci Rep
. 2019 Aug;
9(1):11065.
PMID: 31363131
In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In...
3.
Klungland A, Robertson A
Free Radic Biol Med
. 2016 Nov;
107:62-68.
PMID: 27890639
Recent reports suggest that the Tet enzyme family catalytically oxidize 5-methylcytosine in mammalian cells. The oxidation of 5-methylcytosine can result in three chemically distinct species - 5-hydroxymethylcytsine, 5-formylcytosine, and 5-carboxycytosine....
4.
Vander Zanden C, Rowe R, Broad A, Robertson A, Ho P
Biochemistry
. 2016 Sep;
55(41):5781-5789.
PMID: 27653243
5-Hydroxymethylcytosine (C) is an epigenetic marker that has recently been shown to promote homologous recombination (HR). In this study, we determine the effects of C on the structure, thermodynamics, and...
5.
Weber A, Krawczyk C, Robertson A, Kusnierczyk A, Vagbo C, Schuermann D, et al.
Nat Commun
. 2016 Mar;
7:10806.
PMID: 26932196
Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically established and maintained by DNA methyltransferases and demethylases. Molecular mechanisms of active DNA demethylation began to surface only recently...
6.
Robertson A, Robertson J, Fusser M, Klungland A
Nucleic Acids Res
. 2014 Oct;
42(21):13280-93.
PMID: 25355512
5-hydroxymethylcytosine (5hmC) has been suggested to be involved in various nucleic acid transactions and cellular processes, including transcriptional regulation, demethylation of 5-methylcytosine and stem cell pluripotency. We have identified an...
7.
Robertson A, Dahl J, Klungland A
Nat Chem Biol
. 2014 Jun;
10(7):487-8.
PMID: 24937064
No abstract available.
8.
Solberg A, Robertson A, Aronsen J, Rognmo O, Sjaastad I, Wisloff U, et al.
J Mol Cell Biol
. 2013 Apr;
5(3):194-203.
PMID: 23572141
Mammals have nine homologues of the Escherichia coli AlkB repair protein: Alkbh1-8, and the fat mass and obesity associated protein FTO. In this report, we describe the first functional characterization...
9.
Robertson A, Matson S
J Biol Chem
. 2012 Aug;
287(39):32953-66.
PMID: 22846989
The Escherichia coli very short patch (VSP) repair pathway corrects thymidine-guanine mismatches that result from spontaneous hydrolytic deamination damage of 5-methyl cytosine. The VSP repair pathway requires the Vsr endonuclease,...
10.
Robertson A, Dahl J, Ougland R, Klungland A
Nat Protoc
. 2012 Jan;
7(2):340-50.
PMID: 22281869
We describe a method for the efficient and selective identification of DNA containing the 5-hydroxymethylcytosine (5-hmC) modification. This protocol takes advantage of two proteins: T4 β-glucosyltransferase (β-gt), which converts 5-hmC...