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Ada Yeste

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Articles 23
Citations 2176
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Recent Articles
1.
Sanmarco L, Chao C, Wang Y, Kenison J, Li Z, Rone J, et al.
Nature . 2022 Oct; 611(7937):801-809. PMID: 36266581
Genome-wide association studies have identified risk loci linked to inflammatory bowel disease (IBD)-a complex chronic inflammatory disorder of the gastrointestinal tract. The increasing prevalence of IBD in industrialized countries and...
2.
Levy O, Rothhammer V, Mascanfroni I, Tong Z, Kuai R, De Biasio M, et al.
J Mol Med (Berl) . 2021 Jan; 99(5):663-671. PMID: 33398468
Mesenchymal stem cells (MSCs) are promising candidates for the development of cell-based drug delivery systems for autoimmune inflammatory diseases, such as multiple sclerosis (MS). Here, we investigated the effect of...
3.
Starossom S, Campo Garcia J, Woelfle T, Romero-Suarez S, Olah M, Watanabe F, et al.
Nat Commun . 2019 Jan; 10(1):217. PMID: 30644388
In demyelinating diseases including multiple sclerosis (MS), neural stem cells (NSCs) can replace damaged oligodendrocytes if the local microenvironment supports the required differentiation process. Although chitinase-like proteins (CLPs) form part...
4.
Shan M, Carrillo J, Yeste A, Gutzeit C, Segura-Garzon D, Walland A, et al.
Immunity . 2018 Oct; 49(4):709-724.e8. PMID: 30291028
B cells thwart antigenic aggressions by releasing immunoglobulin M (IgM), IgG, IgA, and IgE, which deploy well-understood effector functions. In contrast, the role of secreted IgD remains mysterious. We found...
5.
Zorrilla-Zubilete M, Yeste A, Quintana F, Toiber D, Mostoslavsky R, Silberman D
J Neurochem . 2017 Oct; 144(2):128-138. PMID: 29049850
Diabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a...
6.
Magri G, Comerma L, Pybus M, Sintes J, Llige D, Segura-Garzon D, et al.
Immunity . 2017 Jul; 47(1):118-134.e8. PMID: 28709802
Secretory immunoglobulin A (SIgA) enhances host-microbiota symbiosis, whereas SIgM remains poorly understood. We found that gut IgM plasma cells (PCs) were more abundant in humans than mice and clonally related...
7.
Longhi M, Vuerich M, Kalbasi A, Kenison J, Yeste A, Csizmadia E, et al.
JCI Insight . 2017 May; 2(9). PMID: 28469075
Unconjugated bilirubin (UCB), a product of heme oxidation, has known immunosuppressant properties but the molecular mechanisms, other than antioxidant effects, remain largely unexplored. We note that UCB modulates T helper...
8.
Goettel J, Gandhi R, Kenison J, Yeste A, Murugaiyan G, Sambanthamoorthy S, et al.
Cell Rep . 2016 Oct; 17(5):1318-1329. PMID: 27783946
Existing therapies for inflammatory bowel disease that are based on broad suppression of inflammation result in variable clinical benefit and unwanted side effects. A potential therapeutic approach for promoting immune...
9.
Yeste A, Takenaka M, Mascanfroni I, Nadeau M, Kenison J, Patel B, et al.
Sci Signal . 2016 Jun; 9(433):ra61. PMID: 27330188
Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex vivo-differentiated...
10.
Sisirak V, Sally B, DAgati V, Martinez-Ortiz W, Ozcakar Z, David J, et al.
Cell . 2016 Jun; 166(1):88-101. PMID: 27293190
Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively....