Ablajan Mahmut
Overview
Explore the profile of Ablajan Mahmut including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
634
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Recent Articles
1.
Vaidya K, Donnelly M, Mahmut A, Jang J, Gee T, Aibo M, et al.
Cardiovasc Pathol
. 2022 Jan;
58:107414.
PMID: 35074515
Background: Calcific aortic valve disease (CAVD), a major cause for surgical aortic valve replacement, currently lacks available pharmacological treatments. Cadherin-11 (Cad11), a promising therapeutic target, promotes aortic valve calcification in...
2.
Farrar E, Hiriart E, Mahmut A, Jagla B, Peal D, Milan D, et al.
Sci Adv
. 2021 Nov;
7(45):eabf7910.
PMID: 34739324
Cell plasticity plays a key role in embryos by maintaining the differentiation potential of progenitors. Whether postnatal somatic cells revert to an embryonic-like naïve state regaining plasticity and redifferentiate into...
3.
Gee T, Richards J, Mahmut A, Butcher J
Biomaterials
. 2021 Jan;
269:120669.
PMID: 33482604
Objective: Calcific aortic valve disease (CAVD) is an actively regulated degenerative disease process. Clinical lesions exhibit marked 3D complexity not represented in current in vitro systems. We here present a...
4.
Nsaibia M, Mahmut A, Mahjoub H, Dahou A, Bouchareb R, Boulanger M, et al.
Heart
. 2016 Jul;
102(23):1915-1921.
PMID: 27378363
Introduction: Structural valve degeneration (SVD) leads to the failure of aortic valve bioprostheses. It is suspected that lipid-derived factors could play a role in SVD. We hypothesised that oxidised low-density...
5.
Mahmut A, Mahjoub H, Boulanger M, Dahou A, Bouchareb R, Capoulade R, et al.
Clin Chim Acta
. 2016 Jan;
455:20-5.
PMID: 26797670
Background: We previously reported that plasma Lp-PLA2 was associated with aortic valve disease progression and degeneration of bioprostheses. Low systemic arterial compliance and high valvuloarterial impedance (Z(va)) are predictors of...
6.
Capoulade R, Chan K, Yeang C, Mathieu P, Bosse Y, Dumesnil J, et al.
J Am Coll Cardiol
. 2015 Sep;
66(11):1236-1246.
PMID: 26361154
Background: Elevated lipoprotein(a) (Lp[a]) is associated with aortic stenosis (AS). Oxidized phospholipids (OxPL) are key mediators of calcification in valvular cells and are carried by Lp(a). Objectives: This study sought...
7.
Bouchareb R, Mahmut A, Nsaibia M, Boulanger M, Dahou A, Lepine J, et al.
Circulation
. 2015 Jul;
132(8):677-90.
PMID: 26224810
Background: Mendelian randomization studies have highlighted that lipoprotein(a) [Lp(a)] was associated with calcific aortic valve disease (CAVD). Lp(a) transports oxidized phospholipids with a high content in lysophosphatidylcholine. Autotaxin (ATX) transforms...
8.
Shayhidin E, Forcellini E, Boulanger M, Mahmut A, Dautrey S, Barbeau X, et al.
Br J Pharmacol
. 2015 Jun;
172(16):4189-99.
PMID: 26031197
Background And Purpose: Ectonucleotide pyrophosphatase/PDE1 (NPP1) is an ectoenzyme, which plays a role in several disorders including calcific aortic valve disease (CAVD). So far, compounds that have been developed as...
9.
Bouchareb R, Cote N, Marie-Chloe-Boulanger , Le Quang K, El Husseini D, Asselin J, et al.
J Mol Cell Cardiol
. 2015 Mar;
82:104-15.
PMID: 25771146
Aims: Calcific aortic valve stenosis (CAVS) is the most common heart valve disease. In the present work we sought to determine the reversibility of mineralization in the aortic valve. Methods...
10.
Mahmut A, Boulanger M, Bouchareb R, Hadji F, Mathieu P
Cardiovasc Res
. 2015 Feb;
106(1):109-20.
PMID: 25644539
Aims: In this study, we sought to determine the role of ecto-nucleotidases and adenosine receptors in calcific aortic valve disease (CAVD). The expression of ecto-nucleotidases, which modify the levels of...