Abhilash Samykutty
Overview
Explore the profile of Abhilash Samykutty including associated specialties, affiliations and a list of published articles.
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Citations
830
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Recent Articles
1.
Samykutty A, Thomas K, McNally M, Hagood J, Chiba A, Thomas A, et al.
Radiol Imaging Cancer
. 2023 May;
5(3):e220180.
PMID: 37233208
Purpose To develop optoacoustic, spectrally distinct, actively targeted gold nanoparticle-based near-infrared probes (trastuzumab [TRA], TRA-Aurelia-1, and TRA-Aurelia-2) that can be individually identifiable at multispectral optoacoustic tomography (MSOT) of human epidermal...
2.
Singh D, Yodun T, Kumar G, Tali J, Tiwari H, Singh J, et al.
Bioorg Chem
. 2022 Jun;
125:105882.
PMID: 35660838
A library of 49 analogs of imidazo[1,2-a]pyridine with 2-halo, aryl, styryl and phenylethynyl-substitution at C-2 position and N-/O-/S-methyl linkage at C-3 position, have been synthesized and evaluated for their anti-proliferative...
3.
MacCuaig W, Samykutty A, Foote J, Luo W, Filatenkov A, Li M, et al.
Pharmaceutics
. 2022 May;
14(5).
PMID: 35631554
Nanoparticles are popular tools utilized to selectively deliver drugs and contrast agents for identification and treatment of disease. To determine the usefulness and translational potential of mesoporous silica nanoparticles (MSNs),...
4.
Singh D, Dheer D, Samykutty A, Shankar R
J Control Release
. 2021 Oct;
340:1-34.
PMID: 34673122
The antibody-drug conjugates (ADCs) are one the fastest growing biotherapeutics in oncology and are still in their infancy in gastrointestinal (GI) cancer for clinical applications to improve patient survival. The...
5.
MacCuaig W, Fouts B, McNally M, Grizzle W, Chuong P, Samykutty A, et al.
ACS Appl Mater Interfaces
. 2021 Oct;
13(42):49614-49630.
PMID: 34653338
Nanoparticles are widely studied as theranostic vehicles for cancer; however, clinical translation has been limited due to poor tumor specificity. Features that maximize tumor uptake remain controversial, particularly when using...
6.
Thomas A, Samykutty A, Gomez-Gutierrez J, Yin W, Egger M, McNally M, et al.
Cancers (Basel)
. 2020 Aug;
12(8).
PMID: 32823919
Pancreatic cancer remains a recalcitrant neoplasm associated with chemoresistance and high fatality. Because it is frequently resistant to apoptosis, exploiting autophagic cell death could offer a new treatment approach. We...
7.
Bhutiani N, Samykutty A, McMasters K, Egilmez N, McNally L
Photoacoustics
. 2018 Dec;
13:46-52.
PMID: 30555786
While particle carriers have potential to revolutionize disease treatment, using these carriers requires knowledge of spatial and temporal biodistribution. The goal of this study was to track orally administered particle...
8.
Samykutty A, Grizzle W, Fouts B, McNally M, Chuong P, Thomas A, et al.
Biomaterials
. 2018 Aug;
182:114-126.
PMID: 30118979
At the intersection of the newly emerging fields of optoacoustic imaging and theranostic nanomedicine, promising clinical progress can be made in dismal prognosis of ovarian cancer. An acidic pH targeted...
9.
Xiao T, Weis J, Gayzik F, Thomas A, Chiba A, Gurcan M, et al.
Photoacoustics
. 2018 Aug;
11:28-35.
PMID: 30105204
Examining the dynamics of an agent in the tumor microenvironment can offer critical insights to the influx rate and accumulation of the agent. Intratumoral kinetic characterization in the setting can...
10.
Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M, et al.
Mol Ther
. 2017 Mar;
25(7):1641-1654.
PMID: 28274798
The intestinal immune system is continuously exposed to massive amounts of nanoparticles derived from food. Whether nanoparticles from plants we eat daily have a role in maintaining intestinal immune homeostasis...