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Abhijit Takawale

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Articles 22
Citations 956
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Recent Articles
1.
Takawale A, Aguilar M, Bouchrit Y, Hiram R
Cells . 2022 Dec; 11(24). PMID: 36552815
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with increased cardiovascular morbidity and mortality. The pathophysiology of AF is characterized by electrical and structural remodeling occurring in the...
2.
Aguilar M, Rose R, Takawale A, Nattel S, Reilly S
Cardiovasc Res . 2021 Mar; 117(7):1645-1661. PMID: 33723575
Hormones are potent endo-, para-, and autocrine endogenous regulators of the function of multiple organs, including the heart. Endocrine dysfunction promotes a number of cardiovascular diseases, including atrial fibrillation (AF)....
3.
Moreira L, Takawale A, Hulsurkar M, Menassa D, Antanaviciute A, Lahiri S, et al.
Nature . 2020 Nov; 587(7834):460-465. PMID: 33149301
Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in humans. Atrial-tissue fibrosis is a central pathophysiological...
4.
Surinkaew S, Aflaki M, Takawale A, Chen Y, Qi X, Gillis M, et al.
Cardiovasc Res . 2018 Jul; 115(1):94-106. PMID: 30016400
Aims: Heart failure (HF) produces left atrial (LA)-selective fibrosis and promotes atrial fibrillation. HF also causes adrenergic activation, which contributes to remodelling via a variety of signalling molecules, including the...
5.
Sakamuri S, Watts R, Takawale A, Wang X, Hernandez-Anzaldo S, Bahitham W, et al.
Sci Rep . 2017 Jul; 7(1):6210. PMID: 28740132
Tissue inhibitor of metalloproteases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs) that regulate tissue extracellular matrix (ECM) turnover. TIMP4 is highly expressed in adipose tissue, its levels are further elevated...
6.
Takawale A, Zhang P, Azad A, Wang W, Wang X, Murray A, et al.
Am J Physiol Heart Circ Physiol . 2017 May; 313(2):H224-H236. PMID: 28550172
Myocardial infarction (MI) results in loss of cardiomyocytes, adverse extracellular matrix (ECM) and structural remodeling, and left ventricular (LV) dilation and dysfunction. Tissue inhibitors of metalloproteinase (TIMPs) inhibit matrix metalloproteinases...
7.
Takawale A, Zhang P, Patel V, Wang X, Oudit G, Kassiri Z
Hypertension . 2017 Apr; 69(6):1092-1103. PMID: 28373589
Myocardial fibrosis is excess accumulation of the extracellular matrix fibrillar collagens. Fibrosis is a key feature of various cardiomyopathies and compromises cardiac systolic and diastolic performance. TIMP1 (tissue inhibitor of...
8.
van der Veen J, Lingrell S, Gao X, Takawale A, Kassiri Z, Vance D, et al.
J Lipid Res . 2017 Feb; 58(4):656-667. PMID: 28159867
Mice lacking phosphatidylethanolamine -methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which...
9.
Jamieson K, Samokhvalov V, Akhnokh M, Lee K, Cho W, Takawale A, et al.
Prostaglandins Other Lipid Mediat . 2017 Jan; 132:47-58. PMID: 28104457
Background: Pathophysiological responses, including cardiovascular complications, often alter with age. Cardioprotective effects of epoxyeicosatrienoic acids (EETs) toward acute myocardial ischemia-reperfusion injury have been well documented. However, biological relevance of EET-evoked...
10.
Fan D, Takawale A, Shen M, Samokhvalov V, Basu R, Patel V, et al.
Hypertension . 2016 Aug; 68(4):937-48. PMID: 27550917
A disintegrin and metalloprotease-17 (ADAM17) belongs to a family of transmembrane enzymes, and it can mediate ectodomain shedding of several membrane-bound molecules. ADAM17 levels are elevated in patients with hypertrophic...