Abdul Hakkim
Overview
Explore the profile of Abdul Hakkim including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
2456
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0
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Recent Articles
1.
Jagadeesan S, Hakkim A
Curr Protoc Mol Biol
. 2018 Sep;
124(1):e65.
PMID: 30204302
RNAi is a powerful reverse genetics tool that has revolutionized genetic studies in model organisms. The bacteriovorous nematode Caenorhabditis elegans can be genetically manipulated by feeding it an Escherichia coli...
2.
Jagadeesan S, Hakkim A
Curr Protoc Mol Biol
. 2018 Sep;
124(1):e70.
PMID: 30192421
Automated or semi-automated high-throughput RNAi screens are highly prone to systematic errors because of multistep repetitive protocols and extensive use of automated instruments. A well-designed RNAi library can help detect...
3.
Labed S, Wani K, Jagadeesan S, Hakkim A, Najibi M, Irazoqui J
Immunity
. 2018 May;
48(5):963-978.e3.
PMID: 29768179
Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense against infection and to microbiota homeostasis. Understanding the mechanisms that regulate such expression is necessary for understanding immune...
4.
Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, et al.
EMBO Rep
. 2018 Mar;
19(5).
PMID: 29523648
When feeds on , some bacteria cross the intestinal barrier and eventually proliferate in the hemocoel. This process is limited by hemocytes through phagocytosis. requires the quorum-sensing regulator RhlR to...
5.
Flores R, Dohrmann S, Schaal C, Hakkim A, Nizet V, Corriden R
Front Immunol
. 2016 Dec;
7:566.
PMID: 28003814
Raloxifene is a selective estrogen receptor modulator typically prescribed for the prevention/treatment of osteoporosis in postmenopausal women. Although raloxifene is known to have anti-inflammatory properties, its effects on human neutrophils,...
6.
Hakkim A, Fuchs T, Martinez N, Hess S, Prinz H, Zychlinsky A, et al.
Nat Chem Biol
. 2010 Dec;
7(2):75-7.
PMID: 21170021
The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional...
7.
Papayannopoulos V, Metzler K, Hakkim A, Zychlinsky A
J Cell Biol
. 2010 Oct;
191(3):677-91.
PMID: 20974816
Neutrophils release decondensed chromatin termed neutrophil extracellular traps (NETs) to trap and kill pathogens extracellularly. Reactive oxygen species are required to initiate NET formation but the downstream molecular mechanism is...
8.
Hakkim A, Furnrohr B, Amann K, Laube B, Abu Abed U, Brinkmann V, et al.
Proc Natl Acad Sci U S A
. 2010 May;
107(21):9813-8.
PMID: 20439745
Systemic lupus erythematosus (SLE) is an autoimmune disease in which patients develop autoantibodies to DNA, histones, and often to neutrophil proteins. These form immune complexes that are pathogenic and may...
9.
Bianchi M, Hakkim A, Brinkmann V, Siler U, Seger R, Zychlinsky A, et al.
Blood
. 2009 Jun;
114(13):2619-22.
PMID: 19541821
Chronic granulomatous disease (CGD) patients have impaired nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function, resulting in poor antimicrobial activity of neutrophils, including the inability to generate neutrophil extracellular traps (NETs)....