Abdellah Allali-Hassani
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Explore the profile of Abdellah Allali-Hassani including associated specialties, affiliations and a list of published articles.
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62
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3147
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Recent Articles
1.
Fnaiche A, Chan H, Paquin A, Gonzalez Suarez N, Vu V, Li F, et al.
ACS Med Chem Lett
. 2023 Dec;
14(12):1746-1753.
PMID: 38116405
The transcription factor YAP-TEAD is the downstream effector of the Hippo pathway which controls cell proliferation, apoptosis, tissue repair, and organ growth. Dysregulation of the Hippo pathway has been correlated...
2.
Fnaiche A, Melin L, Gonzalez Suarez N, Paquin A, Vu V, Li F, et al.
Bioorg Med Chem Lett
. 2023 Sep;
95:129488.
PMID: 37770003
The Hippo pathway regulates organ size and tissue homeostasis by controlling cell proliferation and apoptosis. The YAP-TEAD transcription factor, the downstream effector of the Hippo pathway, regulates the expression of...
3.
Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro
Trush V, Feller C, Li A, Allali-Hassani A, Szewczyk M, Chau I, et al.
Biochim Biophys Acta Gene Regul Mech
. 2022 Jul;
1865(5):194845.
PMID: 35907431
Posttranslational modification of histones plays a critical role in regulation of gene expression. These modifications include methylation and acetylation that work in combination to establish transcriptionally active or repressive chromatin...
4.
Dilworth D, Hanley R, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, et al.
Nat Chem Biol
. 2021 Nov;
18(1):56-63.
PMID: 34782742
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic...
5.
Melin L, Abdullayev S, Fnaiche A, Vu V, Gonzalez Suarez N, Zeng H, et al.
ChemMedChem
. 2021 Jun;
16(19):2982-3002.
PMID: 34164919
The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been...
6.
Shrimp J, Jing Y, Thalalla Gamage S, Nelson K, Han J, Bryson K, et al.
ACS Med Chem Lett
. 2021 Jun;
12(6):887-892.
PMID: 34141066
Remodelin is a putative small molecule inhibitor of the RNA acetyltransferase NAT10 which has shown preclinical efficacy in models of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). Here we...
7.
Ferreira de Freitas R, Liu Y, Szewczyk M, Mehta N, Li F, McLeod D, et al.
J Med Chem
. 2021 Feb;
64(3):1584-1592.
PMID: 33522809
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported...
8.
Allali-Hassani A, Szewczyk M, Ivanochko D, Organ S, Bok J, Ho J, et al.
Nat Commun
. 2019 Dec;
10(1):5759.
PMID: 31848333
PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results...
9.
Fagan V, Johansson C, Gileadi C, Monteiro O, Dunford J, Nibhani R, et al.
J Med Chem
. 2019 Sep;
62(20):9008-9025.
PMID: 31550156
Modifications of histone tails, including lysine/arginine methylation, provide the basis of a "chromatin or histone code". Proteins that contain "reader" domains can bind to these modifications and form specific effector...
10.
Kaustov L, Lemak A, Wu H, Faini M, Fan L, Fang X, et al.
Nucleic Acids Res
. 2019 Aug;
47(17):9433-9447.
PMID: 31400120
Histone H3K4 methylation is an epigenetic mark associated with actively transcribed genes. This modification is catalyzed by the mixed lineage leukaemia (MLL) family of histone methyltransferases including MLL1, MLL2, MLL3,...