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» Authors » Abdalla E A Hassan

Abdalla E A Hassan

Explore the profile of Abdalla E A Hassan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 37
Citations 223
Followers 0
Related Specialties
Biochemistry
Chemistry
Biology
Top 10 Co-Authors
Jia Sheng
Reham A I Abou-Elkhair
John A Secrist 3rd
William B Parker
Paula W Allan
Zhen Huang
Michael J Otto
Raymond F Schinazi
Wen Zhang
Kyoichi A Watanabe
Published In
Nucleosides Nucleotides Nucleic Acids
J Org Chem
Nucleic Acids Res
Eur J Med Chem
Chembiochem
Affiliations
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Recent Articles
11.
3-Trifluoromethylpyrazolones derived nucleosides: Synthesis and antiviral evaluation
Ahmed A, Abou-Elkhair R, El-Torky A, Hassan A
Nucleosides Nucleotides Nucleic Acids . 2019 Apr; 38(8):590-603. PMID: 30929566
Dengue (DENV) viral infection is a global public health problem that infrequently develops life threatening diseases such as dengue hemorrhagic fever (DFS) and dengue shock syndrome (DSS). Middle East respiratory...
12.
Cyano Modification on Uridine Decreases Base-Pairing Stability and Specificity through Neighboring Disruption in RNA Duplex
Mao S, Ranganathan S, Tsai H, Haruehanroengra P, Shen F, Valsangkar V, et al.
Chembiochem . 2018 Oct; 19(24):2558-2565. PMID: 30294879
5-Cyanomethyluridine (cnm U) and 5-cyanouridine (cn U), the two uridine analogues, were synthesized and incorporated into RNA oligonucleotides. Base-pairing stability and specificity studies in RNA duplexes indicated that cnm U...
13.
Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA
Wang R, Ranganathan S, Haruehanroengra P, Mao S, Scalabrin M, Fabris D, et al.
J Biomol Struct Dyn . 2018 Feb; 37(3):551-561. PMID: 29447072
The facile construction of metal-DNA complexes using 'Click' reactions is reported here. A series of 2'-propargyl-modified DNA oligonucleotides were initially synthesized as structure scaffolds and were then modified through 'Click'...
14.
Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation
Abou-Elkhair R, Hassan A, Boykin D, Wilson W
Org Lett . 2016 Sep; 18(18):4714-7. PMID: 27607538
Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to...
15.
6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases
Hassan A, Abou-Elkhair R, Parker W, Allan P, Secrist 3rd J
Bioorg Chem . 2016 Jan; 65:9-16. PMID: 26745284
6-Methylpurine (MeP) is cytotoxic adenine analog that does not exhibit selectivity when administered systemically, and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli...
16.
6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase
Hassan A, Abou-Elkhair R, Parker W, Allan P, Secrist 3rd J
Eur J Med Chem . 2016 Jan; 108:616-622. PMID: 26724729
Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue. 6-Methylpurine...
17.
Synthesis and antimicrobial evaluation of novel pyrazolones and pyrazolone nucleosides
Hassan A, Moustafa A, Tolbah M, Zohdy H, Haikal A
Nucleosides Nucleotides Nucleic Acids . 2012 Nov; 31(11):783-800. PMID: 23145949
The synthesis of a novel series of 4-arylhydrazono-5-methyl-1,2-dihydropyrazol-3-ones 4a-h, and their N (2)-alkyl and acyclo, glucopyranosyl, and ribofuranosyl derivatives is described. K(2)CO(3) catalyzed alkylation of 4a-h with allyl bromide, propargyl...
18.
Hydrogen bond formation between the naturally modified nucleobase and phosphate backbone
Sheng J, Zhang W, Hassan A, Gan J, Soares A, Geng S, et al.
Nucleic Acids Res . 2012 May; 40(16):8111-8. PMID: 22641848
Natural RNAs, especially tRNAs, are extensively modified to tailor structure and function diversities. Uracil is the most modified nucleobase among all natural nucleobases. Interestingly, >76% of uracil modifications are located...
19.
Novel RNA base pair with higher specificity using single selenium atom
Sun H, Sheng J, Hassan A, Jiang S, Gan J, Huang Z
Nucleic Acids Res . 2012 Feb; 40(11):5171-9. PMID: 22323523
Specificity of nucleobase pairing provides essential foundation for genetic information storage, replication, transcription and translation in all living organisms. However, the wobble base pairs, where U in RNA (or T...
20.
Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides
Hassan A, Abou-Elkhair R, Riordan J, Allan P, Parker W, Khare R, et al.
Eur J Med Chem . 2011 Nov; 47(1):167-74. PMID: 22112758
A series of C-6 alkyl, cycloalkyl, and aryl-9-(β-d-ribofuranosyl)purines were synthesized and their substrate activities with Escherichia coli purine nucleoside phosphorylase (E. coli PNP) were evaluated. (Ph(3)P)(4)Pd-mediated cross-coupling reactions of 6-chloro-9-(2,3,5-tri-O-acetyl-β-d-ribofuranosyl)-purine...