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Aaron Robida

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Recent Articles
1.
Puleo N, Ram H, Dziubinski M, Carvette D, Teitel J, Sekhar S, et al.
Mol Cancer Ther . 2025 Jan; PMID: 39873147
Up to 90% of high-grade serous ovarian cancer (HGSC) patients will develop resistance to platinum-based chemotherapy, posing substantial therapeutic challenges due to a lack of universally druggable targets. Leveraging BenevolentAI's...
2.
Reuter M, Lev K, Albo J, Arora H, Liu N, Tan S, et al.
bioRxiv . 2024 Dec; PMID: 39651242
Here, we present M2D2, a two-stage machine learning (ML) pipeline that identifies promising antimicrobial drug combinations, which are crucial for combating drug resistance. M2D2 addresses key challenges in drug combination...
3.
Yuan X, Jiang H, Fu D, Rech J, Robida A, Rajanayake K, et al.
ACS Pharmacol Transl Sci . 2023 Sep; 6(9):1275-1287. PMID: 37705593
Hematopoietic cell transplantation (HCT) is a proven and potentially curable therapy for hematological malignancies and inherited hematological disease. The main risk of HCT is the development of graft versus host...
4.
Yuan X, Jiang H, Fu D, Robida A, Rajanayake K, Yuan H, et al.
Bioorg Med Chem . 2022 Aug; 71:116942. PMID: 35930851
An elevated plasma level of soluble ST2 (sST2) is a risk biomarker for graft-versus-host disease (GVHD) and death in patients receiving hematopoietic cell transplantation (HCT). sST2 functions as a trap...
5.
Ramadan A, Daguindau E, Rech J, Chinnaswamy K, Zhang J, Hura G, et al.
JCI Insight . 2018 Jul; 3(14). PMID: 30046004
Soluble cytokine receptors function as decoy receptors to attenuate cytokine-mediated signaling and modulate downstream cellular responses. Dysregulated overproduction of soluble receptors can be pathological, such as soluble ST2 (sST2), a...