Aaron Patrick
Overview
Explore the profile of Aaron Patrick including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
44
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0
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Recent Articles
1.
Fourie A, Cheng X, Chang L, Greving C, Li X, Knight B, et al.
Sci Rep
. 2024 Jul;
14(1):17515.
PMID: 39080319
The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the...
2.
DeRatt L, Zhang Z, Pietsch C, Cisar J, Zhang X, Wang W, et al.
J Med Chem
. 2024 Jun;
67(13):11254-11272.
PMID: 38889244
Acute myelogenous leukemia (AML), a heterogeneous disease of the blood and bone marrow, is characterized by the inability of myeloblasts to differentiate into mature cell types. Dihydroorotate dehydrogenase (DHODH) is...
3.
Bonneux B, Shareef A, Tcherniuk S, Anson B, De Bruyn S, Verheyen N, et al.
Antiviral Res
. 2024 May;
227:105907.
PMID: 38772503
Respiratory syncytial virus (RSV) can cause pulmonary complications in infants, elderly and immunocompromised patients. While two vaccines and two prophylactic monoclonal antibodies are now available, treatment options are still needed....
4.
Yu X, Abeywickrema P, Bonneux B, Behera I, Anson B, Jacoby E, et al.
Commun Biol
. 2023 Oct;
6(1):1074.
PMID: 37865687
The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation via the RNA dependent RNA polymerase, capping, and...
5.
Lercher L, Simon N, Bergmann A, Tauchert M, Bochmann D, Bashir T, et al.
SLAS Discov
. 2022 May;
27(5):306-313.
PMID: 35513262
The dysregulation of the PRC1/2 complex plays a key role in lineage plasticity in prostate cancer and may be required to maintain neuroendocrine phenotype. [1] CBX2, a key component of...
6.
Shen J, Gai D, Patrick A, Greenleaf W, Chen X
Proc Natl Acad Sci U S A
. 2005 Aug;
102(32):11248-53.
PMID: 16061814
Simian virus 40 large tumor antigen is required for DNA unwinding during viral replication. The helicase-active form of large tumor antigen is a ring-shaped hexamer/double hexamer, which has a positively...