Aaron Mychack
Overview
Explore the profile of Aaron Mychack including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
30
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0
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Recent Articles
1.
Bartlett T, Sisley T, Mychack A, Walker S, Baker R, Rudner D, et al.
Nat Microbiol
. 2024 Mar;
9(3):801-813.
PMID: 38443581
Staphylococcus aureus is a Gram-positive pathogen responsible for antibiotic-resistant infections. To identify vulnerabilities in cell envelope biogenesis that may overcome resistance, we enriched for S. aureus transposon mutants with defects...
2.
Bartlett T, Sisley T, Mychack A, Walker S, Baker R, Rudner D, et al.
bioRxiv
. 2023 May;
PMID: 37162900
is a gram-positive pathogen responsible for life-threatening infections that are difficult to treat due to antibiotic resistance. The identification of new vulnerabilities in essential processes like cell envelope biogenesis represents...
3.
Stone M, Mychack A, Coe K, Walker S
Antimicrob Agents Chemother
. 2023 Apr;
67(5):e0011523.
PMID: 37097175
Antibiotic resistance in bacterial pathogens is an ongoing public health concern. The arylomycins are a class of natural product antibiotics that target the type I signal peptidase, which carries out...
4.
Muscato J, Morris H, Mychack A, Rajagopal M, Baidin V, Hesser A, et al.
J Am Chem Soc
. 2022 Feb;
144(8):3696-3705.
PMID: 35170959
Synthetic lethality occurs when inactivation of two genes is lethal but inactivation of either single gene is not. This phenomenon provides an opportunity for efficient compound discovery. Using differential growth...
5.
Mychack A, Janakiraman A
J Bacteriol
. 2021 Jan;
203(6).
PMID: 33431434
Nearly a quarter of the genome encodes for inner membrane proteins of which approximately a third have unassigned or poorly understood function. We had previously demonstrated that the synergy between...
6.
Mychack A, Amrutha R, Chung C, Cardenas Arevalo K, Reddy M, Janakiraman A
Mol Microbiol
. 2018 Oct;
111(2):317-337.
PMID: 30368949
The bacterial cytoplasmic membrane is a principal site of protein translocation, lipid and peptidoglycan biogenesis, signal transduction, transporters and energy generating components of the respiratory chain. Although 25-30% of bacterial...
7.
Huang K, Mychack A, Tchorzewski L, Janakiraman A
PLoS One
. 2016 Apr;
11(4):e0153337.
PMID: 27088231
Polymerization of a ring-like cytoskeletal structure, the Z-ring, at midcell is a highly conserved feature in virtually all bacteria. The Z-ring is composed of short protofilaments of the tubulin homolog...