Aaron L Halpern
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Explore the profile of Aaron L Halpern including associated specialties, affiliations and a list of published articles.
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27
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8536
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Recent Articles
11.
Bansal V, Halpern A, Axelrod N, Bafna V
Genome Res
. 2008 Aug;
18(8):1336-46.
PMID: 18676820
In comparison to genotypes, knowledge about haplotypes (the combination of alleles present on a single chromosome) is much more useful for whole-genome association studies and for making inferences about human...
12.
Shaw A, Halpern A, Beeson K, Tran B, Venter J, Martiny J
Environ Microbiol
. 2008 Jul;
10(9):2200-10.
PMID: 18637951
The study of microbial diversity patterns is hampered by the enormous diversity of microbial communities and the lack of resources to sample them exhaustively. For many questions about richness and...
13.
Denisov G, Walenz B, Halpern A, Miller J, Axelrod N, Levy S, et al.
Bioinformatics
. 2008 Mar;
24(8):1035-40.
PMID: 18321888
Motivation: We present an algorithm to identify allelic variation given a Whole Genome Shotgun (WGS) assembly of haploid sequences, and to produce a set of haploid consensus sequences rather than...
14.
Williamson S, Rusch D, Yooseph S, Halpern A, Heidelberg K, Glass J, et al.
PLoS One
. 2008 Jan;
3(1):e1456.
PMID: 18213365
Viruses are the most abundant biological entities on our planet. Interactions between viruses and their hosts impact several important biological processes in the world's oceans such as horizontal gene transfer,...
15.
Clark A, Eisen M, Smith D, Bergman C, Oliver B, Markow T, et al.
Nature
. 2007 Nov;
450(7167):203-18.
PMID: 17994087
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of...
16.
Marcy Y, Ishoey T, Lasken R, Stockwell T, Walenz B, Halpern A, et al.
PLoS Genet
. 2007 Sep;
3(9):1702-8.
PMID: 17892324
Since only a small fraction of environmental bacteria are amenable to laboratory culture, there is great interest in genomic sequencing directly from single cells. Sufficient DNA for sequencing can be...
17.
Levy S, Sutton G, Ng P, Feuk L, Halpern A, Walenz B, et al.
PLoS Biol
. 2007 Sep;
5(10):e254.
PMID: 17803354
Presented here is a genome sequence of an individual human. It was produced from approximately 32 million random DNA fragments, sequenced by Sanger dideoxy technology and assembled into 4,528 scaffolds,...
18.
Gibbs R, Rogers J, Katze M, Bumgarner R, Weinstock G, Mardis E, et al.
Science
. 2007 Apr;
316(5822):222-34.
PMID: 17431167
The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar...
19.
Venkatesh B, Kirkness E, Loh Y, Halpern A, Lee A, Johnson J, et al.
PLoS Biol
. 2007 Apr;
5(4):e101.
PMID: 17407382
Owing to their phylogenetic position, cartilaginous fishes (sharks, rays, skates, and chimaeras) provide a critical reference for our understanding of vertebrate genome evolution. The relatively small genome of the elephant...
20.
Rusch D, Halpern A, Sutton G, Heidelberg K, Williamson S, Yooseph S, et al.
PLoS Biol
. 2007 Mar;
5(3):e77.
PMID: 17355176
The world's oceans contain a complex mixture of micro-organisms that are for the most part, uncharacterized both genetically and biochemically. We report here a metagenomic study of the marine planktonic...