Aaron E Engelhart
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Explore the profile of Aaron E Engelhart including associated specialties, affiliations and a list of published articles.
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36
Citations
407
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Recent Articles
1.
Parada Z, Hoog T, Adamala K, Engelhart A
ACS Omega
. 2025 Feb;
10(3):3176-3181.
PMID: 39895733
Guanine-rich sequences exhibit a high degree of polymorphism and can form single-stranded, Watson-Crick duplex, and four-stranded G-quadruplex structures. These sequences have found a wide range of uses in synthetic biology...
2.
Heili J, Heili J, Adamala K, Adamala K, Engelhart A, Engelhart A
Chembiochem
. 2024 Dec;
e202401056.
PMID: 39740778
RNA exhibits remarkable capacity as a functional polymer, with broader catalytic and ligand-binding capability than previously thought. Despite this, the low side chain diversity present in nucleic acids (two purines...
3.
Alejo J, Girodat D, Hammerling M, Willi J, Jewett M, Engelhart A, et al.
PLoS Comput Biol
. 2024 Aug;
20(8):e1012319.
PMID: 39141679
Translocation in protein synthesis entails the efficient and accurate movement of the mRNA-[tRNA]2 substrate through the ribosome after peptide bond formation. An essential conformational change during this process is the...
4.
Hoog T, Pawlak M, Gaut N, Baxter G, Bethel T, Adamala K, et al.
Nat Commun
. 2024 May;
15(1):3863.
PMID: 38769315
Mars is a particularly attractive candidate among known astronomical objects to potentially host life. Results from space exploration missions have provided insights into Martian geochemistry that indicate oxychlorine species, particularly...
5.
Gehlbach E, Robinson A, Engelhart A, Adamala K
Discov Life
. 2024 May;
54(1):2.
PMID: 38765272
Small, spherical vesicles are a widely used chassis for the formation of model protocells and investigating the beginning of compartmentalized evolution. Various methods exist for their preparation, with one of...
6.
Khan P, Aufdembrink L, Adamala K, Engelhart A
RNA
. 2024 Apr;
30(7):891-900.
PMID: 38637016
The SARS-CoV-2 pandemic underscored the need for early, rapid, and widespread pathogen detection tests that are readily accessible. Many existing rapid isothermal detection methods use the recombinase polymerase amplification (RPA),...
7.
Heili J, Stokes K, Gaut N, Deich C, Sharon J, Hoog T, et al.
Cell Syst
. 2024 Jan;
15(1):49-62.e4.
PMID: 38237551
Synthetic minimal cells are a class of bioreactors that have some, but not all, functions of live cells. Here, we report a critical step toward the development of a bottom-up...
8.
Gehlbach E, Robinson A, Engelhart A, Adamala K
bioRxiv
. 2023 Oct;
PMID: 37873423
Small, spherical vesicles are a widely used chassis for the formation of model protocells and investigating the beginning of compartmentalized evolution. Various methods exist for their preparation, with one of...
9.
Sato W, Rasmussen M, Gaut N, Devarajan M, Stokes K, Deich C, et al.
Biotechnol Bioeng
. 2023 May;
120(7):1986-1997.
PMID: 37159417
Synthetic cells, expressing proteins using cell-free transcription-translation (TXTL), is a technology utilized for a variety of applications, such as investigating natural gene pathways, metabolic engineering, drug development or bioinformatics. For...
10.
Sharon J, Dasrath C, Fujiwara A, Snyder A, Blank M, OBrien S, et al.
Nat Commun
. 2023 Apr;
14(1):2257.
PMID: 37080970
Biological computation is becoming a viable and fast-growing alternative to traditional electronic computing. Here we present a biocomputing technology called Trumpet: Transcriptional RNA Universal Multi-Purpose GatE PlaTform. Trumpet combines the...