Joshua C Paulson
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Explore the profile of Joshua C Paulson including associated specialties, affiliations and a list of published articles.
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5
Citations
104
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Recent Articles
1.
van der Feltz C, Nikolai B, Schneider C, Paulson J, Fu X, Hoskins A
RNA
. 2021 Feb;
PMID: 33547186
Genetic, biochemical, and structural studies have elucidated the molecular basis for spliceosome catalysis. Splicing is RNA catalyzed and the essential snRNA and protein factors are well-conserved. However, little is known...
2.
Kaur H, Groubert B, Paulson J, McMillan S, Hoskins A
PLoS One
. 2020 Apr;
15(4):e0229315.
PMID: 32320410
Mutations in the splicing machinery have been implicated in a number of human diseases. Most notably, the U2 small nuclear ribonucleoprotein (snRNP) component SF3b1 has been found to be frequently...
3.
Beier D, Carrocci T, van der Feltz C, Tretbar U, Paulson J, Grabowski N, et al.
Nucleic Acids Res
. 2019 Nov;
47(20):10842-10851.
PMID: 31712821
The DEAD-box family of proteins are ATP-dependent, RNA-binding proteins implicated in many aspects of RNA metabolism. Pre-mRNA splicing in eukaryotes requires three DEAD-box ATPases (Prp5, Prp28 and Sub2), the molecular...
4.
Carrocci T, Paulson J, Hoskins A
RNA
. 2018 May;
24(8):1028-1040.
PMID: 29752352
SF3b1 is an essential component of the U2 snRNP implicated in branch site (BS) recognition and found to be frequently mutated in several human cancers. While recent structures of yeast...
5.
Carrocci T, Zoerner D, Paulson J, Hoskins A
Nucleic Acids Res
. 2017 Jan;
45(8):4837-4852.
PMID: 28062854
RNA and protein components of the spliceosome work together to identify the 5΄ splice site, the 3΄ splice site, and the branchsite (BS) of nascent pre-mRNA. SF3b1 plays a key...