A Thomas Kovala
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Explore the profile of A Thomas Kovala including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
101
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Recent Articles
1.
Butler P, Pascheto I, Lizzi M, St-Onge R, Lanner C, Guo B, et al.
Sci Rep
. 2023 Jan;
13(1):1711.
PMID: 36720913
We have previously shown that neoadjuvant chemotherapy can induce the degradation of tumour ribosomal RNA (rRNA) in patients with advanced breast cancer, a phenomenon we termed "RNA disruption". Extensive tumour...
2.
Edwardson D, Parissenti A, Kovala A
Adv Exp Med Biol
. 2019 Aug;
1152:173-215.
PMID: 31456184
Cancer is the result of a cell's acquisition of a variety of biological capabilities or 'hallmarks' as outlined by Hanahan and Weinberg. These include sustained proliferative signalling, the ability to...
3.
Edwardson D, Boudreau J, Mapletoft J, Lanner C, Kovala A, Parissenti A
PLoS One
. 2017 Sep;
12(9):e0183662.
PMID: 28915246
Tumor Necrosis Factor alpha (TNF-α) has been shown to be released by tumor cells in response to docetaxel, and lipopolysaccharides (LPS), the latter through activation of toll-like receptor 4 (TLR4)....
4.
Boguslawski G, McGlynn P, Harvey K, Kovala A
J Biol Chem
. 2003 Nov;
279(7):5716-24.
PMID: 14625306
SU1498, an inhibitor of vascular endothelial growth factor receptor 2, has been used successfully to study the physiological manifestations of receptor functions. Here we report that in addition to its...
5.
Harvey K, Welch Z, Kovala A, Garcia J, English D
Microvasc Res
. 2002 Apr;
63(3):316-26.
PMID: 11969308
Endothelial cells are dynamic participants in many aspects of host defense, innate immunity, inflammation, angiogenesis, and vasculogenesis, but the interpretation of studies of their responses is often clouded by the...
6.
Boguslawski G, Grogg J, Welch Z, Ciechanowicz S, Sliva D, Kovala A, et al.
Exp Cell Res
. 2002 Mar;
274(2):264-74.
PMID: 11900487
The bioactive lipids sphingosine 1-phosphate (SPP), sphingosylphosphorylcholine, and lysophosphatidic acid play an important role in angiogenesis as a result of their effects on both the migration of endothelial cells (ECs)...