A Sepp
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Explore the profile of A Sepp including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
127
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Recent Articles
1.
Enever C, Pupecka-Swider M, Sepp A
Protein Eng Des Sel
. 2015 Feb;
28(3):59-66.
PMID: 25655396
In addition to the desired specificity and affinity for their respective therapeutic targets, antibody-based drugs must also demonstrate an ability to be manufactured and formulated at the concentrations needed for...
2.
Stubbs R, Sepp A, Hughes D, Johnstone A, King N, Horgan G, et al.
Int J Obes Relat Metab Disord
. 2002 May;
26(6):866-9.
PMID: 12037658
Aim: We assessed the effect of graded increases in exercised-induced energy expenditure (EE) on appetite, daily energy intake (EI), total daily EE and body weight in six lean women using...
3.
Stubbs R, Sepp A, Hughes D, Johnstone A, Horgan G, King N, et al.
Eur J Clin Nutr
. 2002 Feb;
56(2):129-40.
PMID: 11857046
Objective: To assess the effect of graded increases in exercised-induced energy expenditure (EE) on appetite, energy intake (EI), total daily EE and body weight in men living in their normal...
4.
Sepp A, Farrar C, Dorling T, Cairns T, George A, Lechler R
J Immunol Methods
. 2000 Jan;
231(1-2):191-205.
PMID: 10648938
The carbohydrate epitope Galalpha1-3Gal has been shown to be the major target of natural antibodies responsible for hyperacute rejection of porcine tissues transplanted into primates. We have sought to produce...
5.
Takayama S, Chung S, Igarashi Y, Ichikawa Y, Sepp A, Lechler R, et al.
Bioorg Med Chem
. 1999 Apr;
7(2):401-9.
PMID: 10218835
A combined rational and library approach was used to identify bisphosphonates (IC50 = 20 microM) and galactose type 1-N-iminosugar (IC50=45 microM) as novel motifs for selective inhibition of beta-1,4-galactosyltransferase (beta-1,4-GalT)...
6.
Sepp A, Skacel P, Lindstedt R, Lechler R
J Biol Chem
. 1997 Sep;
272(37):23104-10.
PMID: 9287311
The binding of xenoreactive natural antibodies to the Galalpha1-3Galbeta1-4GlcNAc (alpha-galactose) oligosaccharide epitope on pig cells activates the recipient's complement system in pig to primate xenotransplantation. Expression of human alpha-1, 2-fucosyltransferase...
7.
Sepp A, Binns R, Lechler R
J Immunol Methods
. 1996 Sep;
196(2):175-80.
PMID: 8841455
The conventional cytotoxicity detection protocols based on the lactate dehydrogenase (LDH) activity assays rely upon the quantitation of the enzyme activity released into the assay medium upon cell lysis. In...
8.
Sepp A, DODDS A, Anderson M, Campbell R, Willis A, Law S
Protein Sci
. 1993 May;
2(5):706-16.
PMID: 8495193
The complement proteins C3 and C4 have an internal thioester. Upon activation on the surface of a target cell, the thioester becomes exposed and reactive to surface-bound amino and hydroxyl...
9.
Eller M, Sepp A, Toomik R, Ekman P, Jarv J, Ragnarsson U, et al.
Biochem Int
. 1991 Oct;
25(3):453-60.
PMID: 1805790
A set of six different diastereomeric hexapeptides RRASVA, each with a D-amino acid residue successively in the six positions, was synthesized and tested as substrates of protein kinase A. It...
10.
Sepp A, Jarv J
Biochim Biophys Acta
. 1991 Apr;
1077(3):407-12.
PMID: 2029540
Affinity labelling of acetylcholinesterase (EC 3.1.1.7, acetylcholine acetylhydrolase) anionic centre with N,N-dimethyl-2-phenylaziridinium ion accelerates the hydrolysis of non-ionic acetic esters by increasing the rate of the enzyme acylation step at...