A Saldivar
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Explore the profile of A Saldivar including associated specialties, affiliations and a list of published articles.
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15
Citations
203
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Recent Articles
1.
Sham H, Betebenner D, Herrin T, Kumar G, Saldivar A, Vasavanonda S, et al.
Bioorg Med Chem Lett
. 2001 May;
11(11):1351-3.
PMID: 11378352
The HIV protease inhibitor ABT-378 (Lopinavir) is metabolized rapidly and extensively by CYP-3A4 catalyzed oxidation. Three of the major metabolites identified were synthesized and their antiviral (HIV) activities determined.
2.
Chen X, Kempf D, Sham H, GREEN B, Molla A, Korneyeva M, et al.
Bioorg Med Chem Lett
. 1999 Feb;
8(24):3531-6.
PMID: 9934466
The 2-isopropyl thiazolyl group is a highly optimized P3 ligand for C2 symmetry-based HIV protease inhibitors, as exemplified in the drug ritonavir. Here we report that incorporation of this P3...
3.
Sham H, Kempf D, Molla A, Marsh K, Kumar G, Chen C, et al.
Antimicrob Agents Chemother
. 1998 Dec;
42(12):3218-24.
PMID: 9835517
The valine at position 82 (Val 82) in the active site of the human immunodeficiency virus (HIV) protease mutates in response to therapy with the protease inhibitor ritonavir. By using...
4.
Kempf D, Sham H, Marsh K, Flentge C, Betebenner D, GREEN B, et al.
J Med Chem
. 1998 Mar;
41(4):602-17.
PMID: 9484509
The structure-activity studies leading to the potent and clinically efficacious HIV protease inhibitor ritonavir are described. Beginning with the moderately potent and orally bioavailable inhibitor A-80987, systematic investigation of peripheral...
5.
Sham H, Zhao C, Marsh K, Betebenner D, Lin S, Rosenbrook Jr W, et al.
Biochem Biophys Res Commun
. 1996 Aug;
225(2):436-40.
PMID: 8753780
A series of novel, azacyclic ureas which are highly potent inhibitors of the HIV-1 protease (IC50 = 4.1 to < 0.5 nM) were synthesized. Aqueous solubilities of this series of...
6.
Sham H, Zhao C, Stewart K, Betebenner D, Lin S, Park C, et al.
J Med Chem
. 1996 Jan;
39(2):392-7.
PMID: 8558507
The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1) protease that incorporate different ligands for...
7.
Sham H, Zhao C, Marsh K, Betebenner D, Lin S, McDonald E, et al.
Biochem Biophys Res Commun
. 1995 Jun;
211(1):159-65.
PMID: 7779082
A series of novel pseudo-symmetrical and unsymmetrical inhibitors based on the backbone modification of a peptidomimetic were synthesized and found to be highly potent inhibitors of the HIV-1 protease (IC50...
8.
Kempf D, Codacovi L, Wang X, Kohlbrenner W, Wideburg N, Saldivar A, et al.
J Med Chem
. 1993 Feb;
36(3):320-30.
PMID: 8426362
The structure-activity relationships in two series of novel, symmetry-based inhibitors of HIV protease, the enzyme responsible for maturation of the human immunodeficiency virus, are described. Beginning with lead compounds 3-6,...
9.
Lopez-Rubalcava C, Saldivar A, Fernandez-Guasti A
Pharmacol Biochem Behav
. 1992 Oct;
43(2):433-40.
PMID: 1359576
The general purpose of the present study was to analyze the possible interactions between the GABA-benzodiazepine and the serotonergic (5-HT) systems in the anxiolytic action of diazepam and the 5-HT1A...
10.
Kohlbrenner W, Wideburg N, Weigl D, Saldivar A, Chu D
Antimicrob Agents Chemother
. 1992 Jan;
36(1):81-6.
PMID: 1317151
A number of quinolones and related antibacterial compounds were screened for activity against calf thymus topoisomerase II by using the P4 unknotting and DNA breakage assays. Several compounds from different...