A Robert MacLeod
Overview
Explore the profile of A Robert MacLeod including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
72
Citations
4014
Followers
0
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Recent Articles
1.
Lamhamedi-Cherradi S, Maitituoheti M, Menegaz B, Krishnan S, Vetter A, Camacho P, et al.
Nat Commun
. 2022 Jun;
13(1):3057.
PMID: 35650195
Desmoplastic small round cell tumor (DSRCT) is an aggressive, usually incurable sarcoma subtype that predominantly occurs in post-pubertal young males. Recent evidence suggests that the androgen receptor (AR) can promote...
2.
Revenko A, Carnevalli L, Sinclair C, Johnson B, Peter A, Taylor M, et al.
J Immunother Cancer
. 2022 Apr;
10(4).
PMID: 35387780
Background: The Regulatory T cell (Treg) lineage is defined by the transcription factor FOXP3, which controls immune-suppressive gene expression profiles. Tregs are often recruited in high frequencies to the tumor...
3.
Fijen L, Riedl M, Bordone L, Bernstein J, Raasch J, Tachdjian R, et al.
N Engl J Med
. 2022 Mar;
386(11):1026-1033.
PMID: 35294812
Background: Hereditary angioedema is characterized by recurrent and unpredictable swellings that are disabling and potentially fatal. Selective inhibition of plasma prekallikrein production by antisense oligonucleotide treatment (donidalorsen) may reduce the...
4.
Ningarhari M, Caruso S, Hirsch T, Bayard Q, Franconi A, Vedie A, et al.
J Hepatol
. 2022 Feb;
76(5):1242-1243.
PMID: 35221117
No abstract available.
5.
Kapustin A, Davey P, Longmire D, Matthews C, Linnane E, Rustogi N, et al.
Commun Biol
. 2021 Nov;
4(1):1241.
PMID: 34725463
Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. Here we compare intracellular...
6.
Guan J, Clermont A, Pham L, Ustunkaya T, Revenko A, MacLeod A, et al.
Transl Stroke Res
. 2021 Jul;
13(2):287-299.
PMID: 34241810
Plasma kallikrein (PKa) has been implicated in contributing to hemorrhage following thrombolytic therapy; however, its role in spontaneous intracerebral hemorrhage is currently not available. This report investigates the role of...
7.
Vora A, Mondala P, Costello C, MacLeod A, Crews L
STAR Protoc
. 2021 Jun;
2(2):100565.
PMID: 34136833
Interferon regulatory factor 4 (IRF4) is a transcription factor that regulates normal and malignant immune cell development and is implicated in multiple myeloma pathogenesis. This protocol describes the use of...
8.
Sacco A, Federico C, Todoerti K, Ziccheddu B, Palermo V, Giacomini A, et al.
Blood
. 2021 Jun;
138(18):1705-1720.
PMID: 34077955
Alterations in KRAS have been identified as the most recurring somatic variants in the multiple myeloma (MM) mutational landscape. Combining DNA and RNA sequencing, we studied 756 patients and observed...
9.
Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi M, et al.
Mol Cancer
. 2021 Mar;
20(1):56.
PMID: 33766033
No abstract available.
10.
Mondala P, Vora A, Zhou T, Lazzari E, Ladel L, Luo X, et al.
Cell Stem Cell
. 2021 Jan;
28(4):623-636.e9.
PMID: 33476575
In multiple myeloma, inflammatory and anti-viral pathways promote disease progression and cancer stem cell generation. Using diverse pre-clinical models, we investigated the role of interferon regulatory factor 4 (IRF4) in...