A P McMahon
Overview
Explore the profile of A P McMahon including associated specialties, affiliations and a list of published articles.
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Articles
142
Citations
17993
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Recent Articles
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Zhang X, Ramalho-Santos M, McMahon A
Cell
. 2001 Jul;
105(6):781-92.
PMID: 11440720
Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh...
13.
Lewis P, Dunn M, McMahon J, Logan M, Martin J, St-Jacques B, et al.
Cell
. 2001 Jun;
105(5):599-612.
PMID: 11389830
Sonic hedgehog (Shh) signaling from the posterior zone of polarizing activity (ZPA) is the primary determinant of anterior-posterior polarity in the vertebrate limb field. An active signal is produced by...
14.
Bonifas J, Pennypacker S, Chuang P, McMahon A, Williams M, Rosenthal A, et al.
J Invest Dermatol
. 2001 May;
116(5):739-42.
PMID: 11348463
Mutations in hedgehog signaling pathway genes, especially PTC1 and SMO, are pivotal to the development of basal cell carcinomas. The study of basal cell carcinoma gene expression not only may...
15.
Brault V, MOORE R, Kutsch S, Ishibashi M, Rowitch D, McMahon A, et al.
Development
. 2001 Mar;
128(8):1253-64.
PMID: 11262227
beta-Catenin is a central component of both the cadherin-catenin cell adhesion complex and the Wnt signaling pathway. We have investigated the role of beta-catenin during brain morphogenesis, by specifically inactivating...
16.
Chung U, Schipani E, McMahon A, Kronenberg H
J Clin Invest
. 2001 Feb;
107(3):295-304.
PMID: 11160153
Vertebrate skeletogenesis requires a well-coordinated transition from chondrogenesis to osteogenesis. Hypertrophic chondrocytes in the growth plate play a pivotal role in this transition. Parathyroid hormone-related peptide (PTHrP), synthesized in the...
17.
Treier M, OConnell S, Gleiberman A, Price J, Szeto D, Burgess R, et al.
Development
. 2001 Jan;
128(3):377-86.
PMID: 11152636
Pituitary gland development serves as an excellent model system in which to study the emergence of distinct cell types from a common primordium in mammalian organogenesis. We have investigated the...
18.
Kuschert S, Rowitch D, Haenig B, McMahon A, Kispert A
Dev Biol
. 2001 Jan;
229(1):128-40.
PMID: 11133159
The Pax family of transcription factors plays important roles in vertebrate organogenesis. Pax-2 is a critical factor in the development of the mammalian urogenital system. Pax-2 is expressed in the...
19.
Carroll T, McMahon A
J Am Soc Nephrol
. 2000 Nov;
11 Suppl 16:S116-9.
PMID: 11065341
Nearly 50 yr. ago, Clifford Grobstein made the observation that the ureteric bud induced the nephrogenic mesenchyme to undergo tubulogenesis. Since that discovery, scientists have attempted to characterize the molecular...
20.
Hebrok M, Kim S, St Jacques B, McMahon A, Melton D
Development
. 2000 Oct;
127(22):4905-13.
PMID: 11044404
Pancreas organogenesis is regulated by the interaction of distinct signaling pathways that promote or restrict morphogenesis and cell differentiation. Previous work has shown that activin, a TGF(beta+) signaling molecule, permits...