A P McMahon
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Explore the profile of A P McMahon including associated specialties, affiliations and a list of published articles.
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Articles
142
Citations
17993
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Recent Articles
1.
Rajurkar M, Huang H, Cotton J, Brooks J, Sicklick J, McMahon A, et al.
Oncogene
. 2013 Nov;
33(46):5370-8.
PMID: 24276242
Dysregulation of the Hedgehog (Hh)-Gli signaling pathway is implicated in a variety of human cancers, including basal cell carcinoma (BCC), medulloblastoma (MB) and embryonal rhabdhomyosarcoma (eRMS), three principle tumors associated...
2.
Tabin C, McMahon A
Trends Cell Biol
. 2007 Aug;
7(11):442-6.
PMID: 17709003
Hedgehog (HH) proteins are an important class of secreted intercellular signals. The HH signal-transduction pathway is not fully understood, but a number of novel features have been elucidated recently. It...
3.
Clement A, Nguyen M, Roberts E, Garcia M, Boillee S, Rule M, et al.
Science
. 2003 Oct;
302(5642):113-7.
PMID: 14526083
The most common inherited [correct] form of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting adult motor neurons, is caused by dominant mutations in the ubiquitously expressed Cu-Zn superoxide dismutase...
4.
Long F, Zhang X, Karp S, Yang Y, McMahon A
Development
. 2001 Dec;
128(24):5099-108.
PMID: 11748145
Indian hedgehog (Ihh), one of the three mammalian hedgehog (Hh) proteins, coordinates proliferation and differentiation of chondrocytes during endochondral bone development. Smoothened (Smo) is a transmembrane protein that transduces all...
5.
6.
Minina E, Wenzel H, Kreschel C, Karp S, Gaffield W, McMahon A, et al.
Development
. 2001 Nov;
128(22):4523-34.
PMID: 11714677
During endochondral ossification, two secreted signals, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP), have been shown to form a negative feedback loop regulating the onset of hypertrophic differentiation of...
7.
Parr B, Cornish V, Cybulsky M, McMahon A
Dev Biol
. 2001 Sep;
237(2):324-32.
PMID: 11543617
Secreted Wnt proteins regulate many developmental processes in multicellular organisms. We have generated a targeted mutation in the mouse Wnt7b gene. Homozygous Wnt7b mutant mice die at midgestation stages as...
8.
Zhang X, Ramalho-Santos M, McMahon A
Cell
. 2001 Aug;
106(2):781-92.
PMID: 11517919
Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh...
9.
Gritli-Linde A, Lewis P, McMahon A, Linde A
Dev Biol
. 2001 Jul;
236(2):364-86.
PMID: 11476578
Sonic Hedgehog (Shh) and Indian Hedgehog (Ihh) are members of the Hedgehog (Hh) family of signaling molecules known to be involved in embryonic patterning and morphogenesis. The Hh proteins undergo...
10.
Lagutin O, Zhu C, Furuta Y, Rowitch D, McMahon A, Oliver G
Dev Dyn
. 2001 Jul;
221(3):342-9.
PMID: 11458394
A few years ago, three novel murine homeobox genes closely related to the Drosophila sine oculis (so) gene (Six1-3) were isolated and were all included in the Six/so gene family....