A Nazmul H Khan
Overview
Explore the profile of A Nazmul H Khan including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
497
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0
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Recent Articles
1.
Godoy H, Khan A, Vethanayagam R, Grimm M, Singel K, Kolomeyevskaya N, et al.
PLoS One
. 2013 Aug;
8(7):e69631.
PMID: 23922763
The phagocyte NADPH oxidase generates superoxide anion and downstream reactive oxidant intermediates in response to infectious threat, and is a critical mediator of antimicrobial host defense and inflammatory responses. Myeloid-derived...
2.
Chitta K, Khan A, Ersing N, Swaika A, Masood A, Paulus A, et al.
Leuk Lymphoma
. 2013 Jun;
55(3):652-61.
PMID: 23721511
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is currently incurable. To expand the therapeutic armamentarium, we investigated neem leaf extract (NLE) after a patient with CLL...
3.
Grimm M, Vethanayagam R, Almyroudis N, Dennis C, Khan A, DAuria A, et al.
J Immunol
. 2013 Mar;
190(8):4175-84.
PMID: 23509361
Chronic granulomatous disease, an inherited disorder of the NADPH oxidase in which phagocytes are defective in the generation of superoxide anion and downstream reactive oxidant species, is characterized by severe...
4.
Banik D, Khan A, Walseng E, Segal B, Abrams S
PLoS One
. 2012 Oct;
7(9):e45422.
PMID: 23028998
The notion that epigenetic alterations in neoplasia are reversible has provided the rationale to identify epigenetic modifiers for their ability to induce or enhance tumor cell death. Histone deacetylase inhibitors...
5.
Segal B, Grimm M, Khan A, Han W, Blackwell T
Free Radic Biol Med
. 2012 May;
53(1):72-80.
PMID: 22583699
NADPH oxidase is a critical regulator of both antimicrobial host defense and inflammation. Activated in nature by microbes and microbial-derived products, the phagocyte NADPH oxidase is rapidly assembled, and generates...
6.
Masood A, Chitta K, Paulus A, Khan A, Sher T, Ersing N, et al.
Br J Haematol
. 2011 Dec;
157(1):59-66.
PMID: 22171982
Over-expression of anti-apoptotic BCL2 has been reported in chronic lymphocytic leukaemia (CLL), but targeting BCL2 alone did not yield appreciable clinical results. However, it was demonstrated that BCL2 inhibitors enhanced...
7.
Khan A, Tomasi T
Immunol Res
. 2008 Jan;
40(2):164-78.
PMID: 18213528
Epigenetic modifications of chromatin, such as histone acetylation, are involved in repression of tumor antigens and multiple immune genes that are thought to facilitate tumor escape. The status of acetylation...
8.
Khan A, Magner W, Tomasi T
J Transl Med
. 2007 Dec;
5:64.
PMID: 18070359
Background: Numerous immune genes are epigenetically silenced in tumor cells and agents such as histone deacetylase inhibitors (HDACi), which reverse these effects, could potentially be used to develop therapeutic vaccines....
9.
Khan A, Gregorie C, Tomasi T
Cancer Immunol Immunother
. 2007 Nov;
57(5):647-54.
PMID: 18046553
Histone deacetylase inhibitors (HDACi), including trichostatin A (TSA) and valproic acid, can alter the acetylation of histones in chromatin and enhance gene transcription. Previously we demonstrated that HDACi-treated tumor cells...
10.
Tomasi T, Magner W, Khan A
Cancer Immunol Immunother
. 2006 May;
55(10):1159-84.
PMID: 16680460
According to the concept of immune surveillance, the appearance of a tumor indicates that it has earlier evaded host defenses and subsequently must have escaped immunity to evolve into a...