A M Castle
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Explore the profile of A M Castle including associated specialties, affiliations and a list of published articles.
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Citations
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Recent Articles
1.
Huang A, Castle A, Hinton B, Castle J
J Biol Chem
. 2001 Apr;
276(25):22296-306.
PMID: 11301325
Resting secretion of salivary proteins by the parotid gland is sustained in situ between periods of eating by parasympathetic stimulation and has been assumed to involve low level granule exocytosis....
2.
Castle A, Huang A, Castle J
FEBS Lett
. 1998 Dec;
439(3):341-5.
PMID: 9845350
Constitutively secreted proteins have traditionally been believed to be excluded from the regulated secretory pathway. In this work we show that kappa light chain and Fc fragment, two markers of...
3.
Castle A, Castle J
Mol Biol Cell
. 1998 Apr;
9(3):575-83.
PMID: 9487127
We have used coexpression of a salivary basic proline-rich protein (PRP) along with a proline-rich proteoglycan (PRPg) in pituitary AtT-20 cells to examine the regulation of glycosaminoglycan (GAG) biosynthesis and...
4.
Castle A, Huang A, Castle J
J Cell Biol
. 1997 Jul;
138(1):45-54.
PMID: 9214380
Previous studies have suggested that salivary amylase and proline-rich protein are sorted differently when expressed in AtT-20 cells (Castle, A.M., L.E. Stahl, and J.D. Castle. 1992. J. Biol. Chem. 267:13093-...
5.
Castle J, Castle A
J Cell Sci
. 1996 Oct;
109 ( Pt 10):2591-9.
PMID: 8923220
Low doses of the muscarinic agonist pilocarpine (0.1-1 microM) and the beta-adrenergic agonist isoproterenol (0.5-4 nM) stimulate a minor regulated secretory pathway for salivary proteins in rat parotid lobules. Newly...
6.
Stahl L, Wright R, Castle J, Castle A
J Cell Sci
. 1996 Jun;
109 ( Pt 6):1637-45.
PMID: 8799850
When expressed in pituitary AtT-20 cells, parotid proline-rich proteins enter the regulated pathway. Because the short N-terminal domain of a basic proline-rich protein is necessary for efficient export from the...
7.
Castle A, Schwarzbauer J, Wright R, Castle J
J Cell Sci
. 1995 Dec;
108 ( Pt 12):3827-37.
PMID: 8719889
In pituitary-derived AtT-20 cells, recombinant fibronectin containing the N-terminal matrix assembly domain and the C-terminal half of fibronectin does not follow the regulated secretory pathway but instead concentrates in distinct...
8.
Girard L, Castle A, Hand A, Castle J, Mirels L
J Biol Chem
. 1993 Dec;
268(35):26592-601.
PMID: 8253789
We have isolated and characterized cDNA clones derived from a developmentally regulated neonatal rat submandibular gland salivary protein gene called "common salivary protein 1" (CSP1). Identical clones were also identified...
9.
Castle A, Castle J
J Biol Chem
. 1993 Sep;
268(27):20490-6.
PMID: 8376404
We have isolated two cDNAs that encode backbones of proline-rich proteoglycans identified previously in parotids of isoproterenol-treated rats (Blair, A. E., Castle, A. M., and Castle, J. D. (1991) Am....
10.
Castle J, Castle A
Crit Rev Oral Biol Med
. 1993 Jan;
4(3-4):393-8.
PMID: 8373994
Most salivary proteins are stored in secretion granules prior to export from acinar cells in response to neural stimuli. A small subset of these proteins undergo unstimulated secretion without apparent...