A L Phinney
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Explore the profile of A L Phinney including associated specialties, affiliations and a list of published articles.
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10
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1061
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Recent Articles
1.
Amritraj A, Hawkes C, Phinney A, Mount H, Scott C, Westaway D, et al.
Neurobiol Aging
. 2007 Jun;
30(1):54-70.
PMID: 17561313
The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor participates in the trafficking of lysosomal enzymes from the trans-Golgi network or the cell surface to lysosomes. In Alzheimer's disease (AD) brains, marked up-regulation...
2.
Phinney A, Calhoun M, Woods A, Deller T, Jucker M
Eur J Neurosci
. 2004 Apr;
19(7):1731-40.
PMID: 15078547
Denervation of the dentate gyrus by entorhinal cortex lesion has been widely used to study the reorganization of neuronal circuits following central nervous system lesion. Expansion of the non-denervated inner...
3.
McLaurin J, Cecal R, Kierstead M, Tian X, Phinney A, Manea M, et al.
Nat Med
. 2002 Oct;
8(11):1263-9.
PMID: 12379850
Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial...
4.
Janus C, Phinney A, Chishti M, Westaway D
Curr Neurol Neurosci Rep
. 2002 Mar;
1(5):451-7.
PMID: 11898556
Alzheimer's disease (AD) is characterized by deterioration in mental function leading to dementia, deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The major component of plaques is...
5.
Chishti M, Yang D, Janus C, Phinney A, Horne P, Pearson J, et al.
J Biol Chem
. 2001 Mar;
276(24):21562-70.
PMID: 11279122
We have created early-onset transgenic (Tg) models by exploiting the synergistic effects of familial Alzheimer's disease mutations on amyloid beta-peptide (Abeta) biogenesis. TgCRND8 mice encode a double mutant form of...
6.
Calhoun M, Burgermeister P, Phinney A, Stalder M, Tolnay M, Wiederhold K, et al.
Proc Natl Acad Sci U S A
. 1999 Nov;
96(24):14088-93.
PMID: 10570203
Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer's disease pathology, namely the extracellular deposition of amyloid plaques. Here, we describe significant deposition of...
7.
Phinney A, Deller T, Stalder M, Calhoun M, Frotscher M, Sommer B, et al.
J Neurosci
. 1999 Sep;
19(19):8552-9.
PMID: 10493755
A characteristic feature of Alzheimer's disease (AD) is the formation of amyloid plaques in the brain. Although this hallmark pathology has been well described, the biological effects of plaques are...
8.
Phinney A, Calhoun M, Wolfer D, Lipp H, Zheng H, Jucker M
Neuroscience
. 1999 May;
90(4):1207-16.
PMID: 10338291
Aged beta-amyloid precursor protein-null mice were used to investigate the relationship between beta-amyloid precursor protein, hippocampal neuron and synaptic bouton number, and cognitive function. Learning and memory performance of aged...
9.
Calhoun M, Kurth D, Phinney A, Long J, Hengemihle J, Mouton P, et al.
Neurobiol Aging
. 1999 Apr;
19(6):599-606.
PMID: 10192220
A loss of hippocampal neurons and synapses had been considered a hallmark of normal aging and, furthermore, to be a substrate of age-related learning and memory deficits. Recent stereological studies...
10.
Calhoun M, Wiederhold K, Abramowski D, Phinney A, Probst A, Sturchler-Pierrat C, et al.
Nature
. 1998 Oct;
395(6704):755-6.
PMID: 9796810
No abstract available.