A Hallberg
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Explore the profile of A Hallberg including associated specialties, affiliations and a list of published articles.
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93
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921
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Recent Articles
31.
Winiwarter S, Bonham N, Ax F, Hallberg A, Lennernas H, Karlen A
J Med Chem
. 1998 Dec;
41(25):4939-49.
PMID: 9836611
The effective permeability (Peff) in the human jejunum (in vivo) of 22 structurally diverse compounds was correlated with both experimentally determined lipophilicity values and calculated molecular descriptors. The permeability data...
32.
Alterman M, Bjorsne M, Muhlman A, Classon B, Kvarnstrom I, Danielson H, et al.
J Med Chem
. 1998 Sep;
41(20):3782-92.
PMID: 9748353
A study on the use of derivatized carbohydrates as C2-symmetric HIV-1 protease inhibitors has been undertaken. L-Mannaric acid (6) was bis-O-benzylated at C-2 and C-5 and subsequently coupled with amino...
33.
Marelius J, Hansson T, Hallberg A, Aqvist J
J Comput Aided Mol Des
. 1998 Aug;
12(2):119-31.
PMID: 9690172
Binding energy calculations for complexes of mutant and wild-type human dihydrofolate reductases with 2,4-diaminopteridine and 2,4-diaminoquinazoline inhibitors are reported. Quantitative insight into binding energetics of these molecules is obtained from...
34.
Gronskov K, Hallberg A, Brondum-Nielsen K
Hum Genet
. 1998 May;
102(4):440-5.
PMID: 9600241
Fragile X syndrome is usually caused by expansion of a trinucleotide (CGG) repeat in the 5'-untranslated region of the FMR1 gene. However, both deletions and point mutations in FMR1 have...
35.
SJODIN K, Tunek A, Hallberg A
Chem Pharm Bull (Tokyo)
. 1998 May;
46(4):591-601.
PMID: 9579034
One way to minimise systemic side effects of drugs is to design molecules, soft drugs, in such a way that they are metabolically inactivated rapidly after having acted on their...
36.
Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs
Nillroth U, Vrang L, Markgren P, HULTEN J, Hallberg A, Danielson U
Antimicrob Agents Chemother
. 1997 Nov;
41(11):2383-8.
PMID: 9371337
Resistant virus was isolated from virus propagated in cell culture in the presence of the human immunodeficiency virus type 1 (HIV-1) proteinase inhibitor DMP 323, Ro 31-8959, or A-75925. The...
37.
Lamb N, Feingold E, Savage A, Avramopoulos D, Freeman S, Gu Y, et al.
Hum Mol Genet
. 1997 Sep;
6(9):1391-9.
PMID: 9285774
Recent studies of trisomy 21 have shown that altered levels of recombination are associated with maternal non-disjunction occurring at both meiosis I (MI) and meiosis II (MII). To comprehend better...
38.
Avramopoulos D, Kennerknecht I, Barbi G, Eckert D, Delabar J, Maunoury C, et al.
J Med Genet
. 1997 Jul;
34(7):597-600.
PMID: 9222973
We describe a case of apparent trisomy 21 that does not fulfill the criteria for the clinical diagnosis of Down's syndrome (DS). Our patient was subjected to karyotype analysis and...
39.
Schmidt B, Lindman S, Tong W, Lindeberg G, Gogoll A, Lai Z, et al.
J Med Chem
. 1997 Mar;
40(6):903-19.
PMID: 9083479
Disulfide cyclization is a powerful method for reducing the conformational space of a peptide. This in turn may enable the study of its bioactive conformation. Several analogues of angiotensin II...
40.
Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, HULTEN J, et al.
J Med Chem
. 1997 Mar;
40(6):898-902.
PMID: 9083478
Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1' positions, were cocrystallized with HIV-1 protease, and the crystal structures...