A Hallberg
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Explore the profile of A Hallberg including associated specialties, affiliations and a list of published articles.
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93
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921
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Recent Articles
1.
Mohell N, Alfredsson J, Fransson A, Uustalu M, Bystrom S, Gullbo J, et al.
Cell Death Dis
. 2015 Jun;
6:e1794.
PMID: 26086967
Two main causes of platinum resistance are mutation in the tumor suppressor gene TP53 and drug-induced increase in intracellular glutathione concentration. Mutations in TP53 occur in about 50% of human...
2.
Bosnyak S, Welungoda I, Hallberg A, Alterman M, Widdop R, JONES E
Br J Pharmacol
. 2010 Feb;
159(3):709-16.
PMID: 20128808
Background And Purpose: Angiotensin type 2 receptor (AT(2) receptor) stimulation evokes vasodilator effects in vitro and in vivo that oppose the vasoconstrictor effects of angiotensin type 1 receptors (AT(1) receptors)....
3.
Bjelic S, Nervall M, Gutierrez-de-Teran H, Ersmark K, Hallberg A, Aqvist J
Cell Mol Life Sci
. 2007 Jun;
64(17):2285-305.
PMID: 17585371
Plasmepsins are aspartic proteases involved in the degradation of the host cell hemoglobin that is used as a food source by the malaria parasite. Plasmepsins are highly promising as drug...
4.
Rosenstrom U, Skold C, Lindeberg G, Botros M, Nyberg F, Hallberg A, et al.
J Pept Res
. 2004 Oct;
64(5):194-201.
PMID: 15485557
The present study investigates the importance of the amino acid side chains in the octapeptide angiotensin II (Ang II) for binding to the AT2 receptor. A Gly scan was performed...
5.
Ahlsen G, HULTEN J, Shuman C, Poliakov A, Lindgren M, Alterman M, et al.
Antivir Chem Chemother
. 2002 Aug;
13(1):27-37.
PMID: 12180647
Resistance to anti-HIV protease drugs is a major problem in the design of AIDS drugs with long-term efficacy. To identify structural features associated with a certain resistance profile, the inhibitory...
6.
Muhlman A, Lindberg J, Classon B, Unge T, Hallberg A, Samuelsson B
J Med Chem
. 2001 Oct;
44(21):3407-16.
PMID: 11585446
The synthesis of novel, potent, diol-based HIV-1 protease inhibitors, having phenethyl groups (-CH(2)CH(2)Ph) in P1/P1' position is described. An intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal 16 was the key step in...
7.
Muhlman A, Classon B, Hallberg A, Samuelsson B
J Med Chem
. 2001 Oct;
44(21):3402-6.
PMID: 11585445
The synthesis of novel, potent diol-based HIV-1 protease inhibitors, having either -SAr, -SCH(2)Ar, or -SCH(2)R groups as P1/P1' substituents is described. They can be prepared using a straightforward synthesis involving...
8.
Pyring D, Lindberg J, Rosenquist A , Zuccarello G, Kvarnstrom I, Zhang H, et al.
J Med Chem
. 2001 Sep;
44(19):3083-91.
PMID: 11543677
Implementation of derivatized carbohydrates as C(2)-symmetric HIV-1 protease inhibitors has previously been reported. With the objective of improving the anti-HIV activity of such compounds, we synthesized a series of fluoro...
9.
Nilsson P, Larhed M, Hallberg A
J Am Chem Soc
. 2001 Aug;
123(34):8217-25.
PMID: 11516272
This article describes the development of new auxiliary-accelerated Heck multiarylations by intramolecular presentation of the oxidative addition complex. The introduction of a specific, palladium-coordinating dimethylamino group allows for the desired...
10.
Kolmodin K, Aqvist J, Queener S, Hallberg A
J Med Chem
. 2001 Jul;
44(15):2391-402.
PMID: 11448221
A series of lipophilic soft drugs structurally related to the nonclassical dihydrofolate reductase (DHFR) inhibitors trimetrexate and piritrexim have been designed, synthesized, and evaluated in DHFR assays, with special emphasis...