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» Authors » A H Palamakumbura

A H Palamakumbura

Explore the profile of A H Palamakumbura including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 180
Followers 0
Related Specialties
Biochemistry
Oncology
Molecular Biology
Top 10 Co-Authors
P C Trackman
J E Erman
L B Vitello
S R Vora
B M Kleber
P NGuessan
H Renz
W N Pappano
T A L J J Bronckers
M C Foshay
Published In
Biochemistry
Oncogene
J Biol Chem
Calcif Tissue Int
Affiliations
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Recent Articles
1.
Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling
Palamakumbura A, Vora S, Nugent M, Kirsch K, Sonenshein G, Trackman P
Oncogene . 2009 Jul; 28(38):3390-400. PMID: 19597471
Enhanced RAS signaling and decreased androgen dependence of prostate cancer cells accompany poor clinical outcomes. Elevated autocrine fibroblast growth factors 2 (FGF-2) signaling promotes prostate cancer cell growth and survival....
2.
Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype
Pischon N, Maki J, Weisshaupt P, Heng N, Palamakumbura A, NGuessan P, et al.
Calcif Tissue Int . 2009 May; 85(2):119-26. PMID: 19458888
Lysyl oxidase (LOX) catalyzes cross-linking of elastin and collagen, which is essential for the structural integrity and function of bone tissue. The present study examined the role of Lox gene...
3.
Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures
Uzel M, Scott I, Palamakumbura A, Pappano W, HONG H, Greenspan D, et al.
J Biol Chem . 2001 Apr; 276(25):22537-43. PMID: 11313359
Lysyl oxidase catalyzes the final enzymatic step required for collagen and elastin cross-linking in extracellular matrix biosynthesis. Pro-lysyl oxidase is processed by procollagen C-proteinase activity, which also removes the C-propeptides...
4.
Oxidation of the His-52 --> Leu mutant of cytochrome c peroxidase by p-nitroperoxybenzoic acid: role of the distal histidine in hydroperoxide activation
Palamakumbura A, Vitello L, Erman J
Biochemistry . 1999 Nov; 38(47):15653-8. PMID: 10569951
Both cytochrome c peroxidase (CcP) and a mutant cytochrome c peroxidase in which the distal histidine has been replaced by leucine, CcP(H52L), are converted to hydroxy-ligated derivatives at alkaline pH....
5.
Oxidation of cytochrome c peroxidase to compound I by peroxyacids: evidence for rate-limiting diffusion through the protein matrix
Palamakumbura A, Foshay M, Vitello L, Erman J
Biochemistry . 1999 Nov; 38(47):15647-52. PMID: 10569950
The rate of the reaction between p-nitroperoxybenzoic acid and cytochrome c peroxidase (CcP) has been investigated as a function of pH and ionic strength. The pH dependence of the reaction...