A E Murthy
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Explore the profile of A E Murthy including associated specialties, affiliations and a list of published articles.
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6
Citations
166
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Recent Articles
1.
Cowley G, Murthy A, Parry D, Schneider G, Korf B, Upadhyaya M, et al.
Somat Cell Mol Genet
. 1999 Jan;
24(2):107-19.
PMID: 9919310
Neurofibromatosis type 1 (NF1) is a common genetic disorder caused by inactivation of neurofibromin, a protein capable of modulating signal transduction by activating Ras-GTPase activity. We have used cDNA cloning...
2.
Murthy A, Bernards A, Church D, Wasmuth J, Gusella J
DNA Cell Biol
. 1996 Sep;
15(9):727-35.
PMID: 8836031
The tetratricopeptide repeat (TPR) is a degenerate, repeating amino acid motif of 34 residues that has been identified in a variety of proteins; however, no biochemical function has been established...
3.
Weissbach L, Settleman J, Kalady M, Snijders A, Murthy A, Yan Y, et al.
J Biol Chem
. 1994 Aug;
269(32):20517-21.
PMID: 8051149
Conversion of active GTP-bound Ras to its inactive GDP-bound form is catalyzed by GTPase-activating proteins (GAPs). Two mammalian Ras-specific GAPs, p120GAP and neurofibromin, the product of the NF1 tumor suppressor...
4.
Bernards A, Snijders A, Hannigan G, Murthy A, Gusella J
Hum Mol Genet
. 1993 Jun;
2(6):645-50.
PMID: 8353485
To identify evolutionary conserved domains and facilitate the recognition of potentially significant mutations in NF1 patients or tumors, we have determined the complete approximately 12 kb sequence of mouse neurofibromatosis...
5.
The I, Murthy A, Hannigan G, Jacoby L, Menon A, Gusella J, et al.
Nat Genet
. 1993 Jan;
3(1):62-6.
PMID: 8490657
The introduction of human chromosome 17 suppresses the tumourigenicity of a neuroblastoma cell line in the absence of any effects on in vitro growth and the neurofibromatosis type 1 (NF1)...
6.
Bernards A, Haase V, Murthy A, Menon A, Hannigan G, Gusella J
DNA Cell Biol
. 1992 Dec;
11(10):727-34.
PMID: 1457041
Neurofibromatosis type 1 (NF1) is caused by mutations in a large gene on chromosome 17q11.2. Previously described partial cDNAs for this gene predicted a protein related to yeast IRA1/IRA2 and...