J Settleman
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Explore the profile of J Settleman including associated specialties, affiliations and a list of published articles.
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49
Citations
3502
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Recent Articles
1.
Ducker G, Atreya C, Simko J, Hom Y, Matli M, Benes C, et al.
Oncogene
. 2013 Apr;
33(12):1590-600.
PMID: 23542178
The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But mTOR is not an oncogene, and which...
2.
Heckman-Stoddard B, Vargo-Gogola T, Herrick M, Visbal A, Lewis M, Settleman J, et al.
Dev Biol
. 2011 Sep;
360(1):1-10.
PMID: 21945077
P190A and p190B Rho GTPase activating proteins (GAPs) are essential genes that have distinct, but overlapping roles in the developing nervous system. Previous studies from our laboratory demonstrated that p190B...
3.
Singh A, Settleman J
Oncogene
. 2010 Jun;
29(34):4741-51.
PMID: 20531305
Tumors are cellularly and molecularly heterogeneous, with subsets of undifferentiated cancer cells exhibiting stem cell-like features (CSCs). Epithelial to mesenchymal transitions (EMT) are transdifferentiation programs that are required for tissue...
4.
Haber D, BELL D, Sordella R, Kwak E, Godin-Heymann N, Sharma S, et al.
Cold Spring Harb Symp Quant Biol
. 2006 Jul;
70:419-26.
PMID: 16869779
Somatic mutations within the kinase domain of the epidermal growth factor receptor (EGFR) are present in approximately 10% of non-small-cell lung cancer (NSCLC), with an increased frequency in adenocarcinomas arising...
5.
Settleman J
Dev Cell
. 2001 Nov;
1(3):321-31.
PMID: 11702944
The small GTPases of the Rho subfamily constitute a group of evolutionarily conserved proteins that mediate signaling pathways that regulate a variety of cellular processes, many of which are associated...
6.
Molnar G, Dagher M, Geiszt M, Settleman J, Ligeti E
Biochemistry
. 2001 Aug;
40(35):10542-9.
PMID: 11523996
The role of prenylation in the interaction of Rho-family small GTPases with their GTPase activating proteins (GAPs) was investigated. Prenylated and nonprenylated small GTPases were expressed in Sf9 insect cells...
7.
Brouns M, Matheson S, Settleman J
Nat Cell Biol
. 2001 Apr;
3(4):361-7.
PMID: 11283609
The Src tyrosine kinases have been implicated in several aspects of neural development and nervous system function; however, their relevant substrates in brain and their mechanism of action in neurons...
8.
Classon M, Settleman J
Semin Cancer Biol
. 2001 Feb;
10(6):393-7.
PMID: 11170861
No abstract available.
9.
Brouns M, Matheson S, Hu K, Delalle I, CAVINESS V, Silver J, et al.
Development
. 2000 Oct;
127(22):4891-903.
PMID: 11044403
Rho GTPases direct actin rearrangements in response to a variety of extracellular signals. P190 RhoGAP (GTPase activating protein) is a potent Rho regulator that mediates integrin-dependent adhesion signaling in cultured...
10.
Symons M, Settleman J
Trends Cell Biol
. 2000 Sep;
10(10):415-9.
PMID: 10998597
Rho family GTPases control a large variety of biological processes. Cycling of Rho proteins between the GDP-bound and the GTP-bound state is controlled by several classes of regulatory proteins. In...