A A De Graaf
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Explore the profile of A A De Graaf including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1114
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Recent Articles
1.
Binsl T, De Graaf A, Venema K, Heringa J, Maathuis A, De Waard P, et al.
Benef Microbes
. 2011 Aug;
1(4):391-405.
PMID: 21831778
This paper explores human gut bacterial metabolism of starch using a combined analytical and computational modelling approach for metabolite and flux analysis. Non-steady-state isotopic labelling experiments were performed with human...
2.
Binsl T, De Graaf A, Venema K, Heringa J, Maathuis A, De Waard P, et al.
Benef Microbes
. 2011 Aug;
1(4):S1-7.
PMID: 21831768
No abstract available.
3.
Marx A, Striegel K, De Graaf A, Sahm H, Eggeling L
Biotechnol Bioeng
. 2008 Jul;
56(2):168-80.
PMID: 18636622
To evaluate the importance of reactions within the central metabolism under different flux burdens the fluxes within the pentose phosphate pathway (PPP), as well as the other reactions of the...
4.
Meesters R, van Eijk H, ten Have G, De Graaf A, Venema K, van Rossum B, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2007 Apr;
854(1-2):57-62.
PMID: 17452031
A new method involving zinc sulphate deproteinization was developed to study short chain fatty acids (SCFA) production in the colon and subsequent occurrence of SCFA in blood. SCFA were baseline...
5.
Drysch A, El Massaoudi M, Wiechert W, De Graaf A, Takors R
Biotechnol Bioeng
. 2004 Feb;
85(5):497-505.
PMID: 14760690
Using our recently developed sensor reactor approach, lysine-producing, nongrowing Corynebacterium glutamicum MH20-22B cells were subjected to serial (13)C-labeling experiments for flux analysis during the leucine-limited fed-batch production phase in a...
6.
Drysch A, El Massaoudi M, Mack C, Takors R, De Graaf A, Sahm H
Metab Eng
. 2003 Jul;
5(2):96-107.
PMID: 12850132
Corynebacterium glutamicum is intensively used for the industrial large-scale (fed-) batch production of amino acids, especially glutamate and lysine. However, metabolic flux analyses based on 13C-labeling experiments of this organism...
7.
Flores S, Gosset G, Flores N, De Graaf A, Bolivar F
Metab Eng
. 2002 May;
4(2):124-37.
PMID: 12009792
We have developed Escherichia coli strains that internalize glucose utilizing the GalP permease instead of the phosphoenolpyruvate:carbohydrate phosphotransferase system. It has been demonstrated that a strain with these modifications (PTS(-)Glc(+))...
8.
De Graaf A, Eggeling L, Sahm H
Adv Biochem Eng Biotechnol
. 2002 Jan;
73:9-29.
PMID: 11816814
Corynebacterium glutamicum has been used since several decades for the large-scale production of amino acids, esp. L-glutamate and L-lysine. After initial successes of random mutagenesis and screening approaches, further strain...
9.
Petersen S, Mack C, De Graaf A, Riedel C, Eikmanns B, Sahm H
Metab Eng
. 2001 Oct;
3(4):344-61.
PMID: 11676569
Corynebacterium glutamicum possesses high in vivo activity of the gluconeogenic phosphoenolpyruvate carboxykinase (PEPCk) during growth on glucose, resulting together with anaplerotic carboxylation reactions in a PEP/pyruvate/oxaloacetate substrate cycle. The present...
10.
Wiechert W, Mollney M, Petersen S, De Graaf A
Metab Eng
. 2001 Jul;
3(3):265-83.
PMID: 11461148
A general methodology is presented for the modeling, simulation, design, evaluation, and statistical analysis of (13)C-labeling experiments for metabolic flux analysis. The universal software framework 13C-FLUX was implemented to support...