Perpetuation of Inflammation Associated with Experimental Arthritis: the Role of Macrophage Activation by Neutrophilic Myeloperoxidase

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 1999 Feb 2

PMID 9927230

Citations 6

Authors

M P Gelderman

R Stuart

D Vigerust

S Fuhrmann

D L Lefkowitz

R C Allen

S S Lefkowitz

S Graham

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoarticular arthritis was induced in female Lewis rats by injection of streptococcal cell wall extracts (PG-APS). After swelling and erythema subsided, joints were re-injected with one of the following: porcine MPO or partially inactivated MPO (iMPO). Injection with either MPO or iMPO induced a 'flare' of experimental RA. Blocking the Mphi-mannose receptor by mannans, ablated exacerbation of disease. These results indicate that MPO or iMPO can play a pivotal role in the perpetuation but not initiation of this RA model.

Citing Articles

Assessing the Impact of Influenza Vaccination Timing on Experimental Arthritis: Effects on Disease Progression and Inflammatory Biomarkers.

Tarjanyi V, Menes A, Hamid L, Kurucz A, Priksz D, Varga B Int J Mol Sci. 2024; 25(6).

PMID: 38542266 PMC: 10969894. DOI: 10.3390/ijms25063292.

d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation.

Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz G, Schmidt S, Chau C Proc Natl Acad Sci U S A. 2021; 118(44).

PMID: 34702739 PMC: 8673064. DOI: 10.1073/pnas.2107663118.

Different behavior of myeloperoxidase in two rodent amoebic liver abscess models.

Cruz-Baquero A, Cardenas Jaramillo L, Gutierrez-Meza M, Jarillo-Luna R, Campos-Rodriguez R, Rivera-Aguilar V PLoS One. 2017; 12(8):e0182480.

PMID: 28796788 PMC: 5552100. DOI: 10.1371/journal.pone.0182480.

A review of the proposed role of neutrophils in rodent amebic liver abscess models.

Campos-Rodriguez R, Gutierrez-Meza M, Jarillo-Luna R, Drago-Serrano M, Abarca-Rojano E, Ventura-Juarez J Parasite. 2016; 23:6.

PMID: 26880421 PMC: 4754534. DOI: 10.1051/parasite/2016006.

Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target.

Forghani R, Wojtkiewicz G, Zhang Y, Seeburg D, Bautz B, Pulli B Radiology. 2012; 263(2):451-60.

PMID: 22438365 PMC: 3329272. DOI: 10.1148/radiol.12111593.

References

Brennan F, Maini R, Feldmann M . TNF alpha--a pivotal role in rheumatoid arthritis?. Br J Rheumatol. 1992; 31(5):293-8. DOI: 10.1093/rheumatology/31.5.293. View

Mertz A, Batsford S, Curschellas E, Kist M, Gondolf K . Cationic Yersinia antigen-induced chronic allergic arthritis in rats. A model for reactive arthritis in humans. J Clin Invest. 1991; 88(2):632-42. PMC: 295402. DOI: 10.1172/JCI115348. View

Chu C, Field M, Feldmann M, Maini R . Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum. 1991; 34(9):1125-32. DOI: 10.1002/art.1780340908. View

Gasson J . Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood. 1991; 77(6):1131-45. View

Shepherd V, Hoidal J . Clearance of neutrophil-derived myeloperoxidase by the macrophage mannose receptor. Am J Respir Cell Mol Biol. 1990; 2(4):335-40. DOI: 10.1165/ajrcmb/2.4.335. View

Davies E, Williams B, Campbell A . Synovial fluid polymorphonuclear leucocytes from patients with rheumatoid arthritis have reduced MPO and NADPH-oxidase activity. Br J Rheumatol. 1990; 29(6):415-21. DOI: 10.1093/rheumatology/29.6.415. View

Edwards S, Nurcombe H, Hart C . Oxidative inactivation of myeloperoxidase released from human neutrophils. Biochem J. 1987; 245(3):925-8. PMC: 1148221. DOI: 10.1042/bj2450925. View

Edwards S, Hughes V, Barlow J, Bucknall R . Immunological detection of myeloperoxidase in synovial fluid from patients with rheumatoid arthritis. Biochem J. 1988; 250(1):81-5. PMC: 1148818. DOI: 10.1042/bj2500081. View

Bozeman P, Hoidal J, Shepherd V . Oxidant-mediated inhibition of ligand uptake by the macrophage mannose receptor. J Biol Chem. 1988; 263(3):1240-7. View

10.

Bradley P, Christensen R, ROTHSTEIN G . Cellular and extracellular myeloperoxidase in pyogenic inflammation. Blood. 1982; 60(3):618-22. View

11.

Sung S, Nelson R, Silverstein S . Yeast mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages. J Cell Biol. 1983; 96(1):160-6. PMC: 2112273. DOI: 10.1083/jcb.96.1.160. View

12.

van den Berg W, van de Putte L, Zwarts W, Joosten L . Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice. J Clin Invest. 1984; 74(5):1850-9. PMC: 425365. DOI: 10.1172/JCI111604. View

13.

Lincoln J, Lefkowitz D, Cain T, Castro A, Mills K, Lefkowitz S . Exogenous myeloperoxidase enhances bacterial phagocytosis and intracellular killing by macrophages. Infect Immun. 1995; 63(8):3042-7. PMC: 173414. DOI: 10.1128/iai.63.8.3042-3047.1995. View

14.

Lichtman S, Wang J, Sartor R, Zhang C, Bender D, DALLDORF F . Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, bacteria, and bacterial polymers. Infect Immun. 1995; 63(6):2295-301. PMC: 173300. DOI: 10.1128/iai.63.6.2295-2301.1995. View

15.

Gaston J . The role of infection in inflammatory arthritis. QJM. 1994; 87(11):647-51. View

16.

Sewell K, Trentham D . Pathogenesis of rheumatoid arthritis. Lancet. 1993; 341(8840):283-6. DOI: 10.1016/0140-6736(93)92627-6. View

17.

Rathanaswami P, Hachicha M, Wong W, Schall T, McColl S . Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on interleukin-8 gene expression in synovial fibroblasts. Evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation. Arthritis Rheum. 1993; 36(9):1295-304. DOI: 10.1002/art.1780360914. View

18.

Cutolo M, Sulli A, Barone A, Seriolo B, Accardo S . Macrophages, synovial tissue and rheumatoid arthritis. Clin Exp Rheumatol. 1993; 11(3):331-9. View

19.

Wahl S, Allen J, Costa G, Wong H, Dasch J . Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J Exp Med. 1993; 177(1):225-30. PMC: 2190857. DOI: 10.1084/jem.177.1.225. View

20.

Gay S, Gay R, Koopman W . Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?. Ann Rheum Dis. 1993; 52 Suppl 1:S39-47. PMC: 1035025. DOI: 10.1136/ard.52.suppl_1.s39. View