G-CSF and GM-CSF As Therapeutic Targets in Rheumatoid Arthritis

Overview

Journal Nat Rev Rheumatol

Specialty Rheumatology

Date 2009 Oct 3

PMID 19798030

Citations 77

Authors

Ann L Cornish

Ian K Campbell

Brent S McKenzie

Simon Chatfield

Ian P Wicks

Affiliations

Soon will be listed here.

Abstract

Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are well-recognized regulators of hematopoiesis and have an established role as growth factors in clinical practice. G-CSF and GM-CSF regulate myeloid cell production, differentiation and activation, and might also be important for driving inflammatory responses. Inappropriate engagement of this pathway could be a critical amplification mechanism when maladaptive immune responses predispose to autoimmunity and sterile tissue inflammation. We postulate that antagonism of G-CSF or GM-CSF could represent a novel therapeutic approach for a variety of autoimmune-mediated inflammatory diseases, including rheumatoid arthritis.

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