Cationic Yersinia Antigen-induced Chronic Allergic Arthritis in Rats. A Model for Reactive Arthritis in Humans

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1991 Aug 1

PMID 1864972

Citations 11

Authors

A K Mertz

S R Batsford

E Curschellas

M J Kist

K B Gondolf

Affiliations

Soon will be listed here.

Abstract

Cationic antigens are known to have considerable arthritogenic potential in experimental systems. During a systematic search for suitable, naturally occurring candidates an intracellular protein was isolated from the ribosomal pellet of Yersinia enterocolitica 0:3, a bacterial strain associated with reactive arthritis in humans. The protein is highly cationic, contains two 19-kD polypeptide chains linked by a disulfide bond, and reveals a strong tendency for spontaneous aggregation. It is suggested to be a nucleic acid binding protein. We tested this antigen for its ability to induce arthritis after intra-articular challenge in preimmunized rats. An acute inflammatory phase followed by transition to chronicity was observed both by technetium-99m scintigraphy and from histology. Massive polymorphonuclear leucocyte infiltration of the synovium was seen early on and fibrosis and thickening of the joint capsule occurred in later stages. Control groups showed no evidence of inflammation. Western blot and ELISA analysis of unselected sera from Yersinia enterocolitica 0:3-infected patients revealed antibodies to the antigen in the majority of cases, whereas healthy individuals rarely reacted. This is the first report of a naturally occurring cationic antigen capable of inducing immunologic tissue injury; it justifies the speculation that cationic antigens from prokaryotic cells could trigger reactive arthritis in humans.

Citing Articles

Induction of Experimental Arthritis by Borrelial Lipoprotein and CpG Motifs: Are Toll-Like Receptors 2, 4, 9 or CD-14 Involved?.

Batsford S, Dunn J, Mihatsch M Open Rheumatol J. 2011; 5:18-23.

PMID: 21804904 PMC: 3141342. DOI: 10.2174/1874312901105010018.

Influence of the electric charge of the antigen and the immune complex (IC) lattice on the IC activation of human complement.

Michelin M, Crott L, Assis-Pandochi A, Coimbra T, Teixeira J, Barbosa J Int J Exp Pathol. 2002; 83(2):105-10.

PMID: 12084047 PMC: 2517671. DOI: 10.1046/j.1365-2613.2002.00224.x.

Construction of urease-negative mutants of Yersinia enterocolitica serotypes O:3 and o:8: role of urease in virulence and arthritogenicity.

Gripenberg-Lerche C, Zhang L, Ahtonen P, TOIVANEN P, Skurnik M Infect Immun. 2000; 68(2):942-7.

PMID: 10639468 PMC: 97227. DOI: 10.1128/IAI.68.2.942-947.2000.

Perpetuation of inflammation associated with experimental arthritis: the role of macrophage activation by neutrophilic myeloperoxidase.

Gelderman M, Stuart R, Vigerust D, Fuhrmann S, Lefkowitz D, Allen R Mediators Inflamm. 1999; 7(6):381-9.

PMID: 9927230 PMC: 1781873. DOI: 10.1080/09629359890758.

Yersinia enterocolitica: the charisma continues.

Bottone E Clin Microbiol Rev. 1997; 10(2):257-76.

PMID: 9105754 PMC: 172919. DOI: 10.1128/CMR.10.2.257.

References

Stanescu R, Leibovich S . The negative charge of articular cartilage surfaces. An electron microscopic study using cationized ferritin. J Bone Joint Surg Am. 1982; 64(3):388-98. View

Lathe R, Buc H, Lecocq J, Bautz E . Prokaryotic histone-like protein interacting with RNA polymerase. Proc Natl Acad Sci U S A. 1980; 77(6):3548-52. PMC: 349654. DOI: 10.1073/pnas.77.6.3548. View

Kruijsen M, van den Berg W, van de Putte L, Van Den Broek W . Detection and quantification of experimental joint inflammation in mice by measurement of 99mTc-pertechnetate uptake. Agents Actions. 1981; 11(6-7):640-2. DOI: 10.1007/BF01978775. View

Oite T, Batsford S, Mihatsch M, Takamiya H, Vogt A . Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted, cationized antigen. J Exp Med. 1982; 155(2):460-74. PMC: 2186608. DOI: 10.1084/jem.155.2.460. View

van den Berg W, van Beusekom H, van de Putte L, Zwarts W, van der Sluis M . Antigen handling in antigen-induced arthritis in mice: an autoradiographic and immunofluorescence study using whole joint sections. Am J Pathol. 1982; 108(1):9-16. PMC: 1916019. View

Batsford S, Takamiya M, Vogt A . A model of in situ immune complex glomerulonephritis in the rat employing cationized ferritin. Clin Nephrol. 1980; 14(5):211-6. View

Sperling R, Wachtel E . The histones. Adv Protein Chem. 1981; 34:1-60. DOI: 10.1016/s0065-3233(08)60517-3. View

Baldassare A, Weiss T, Tsai C, Arthur R, Moore T, Zuckner J . Immunoprotein deposition in synovial tissue in Reiter's syndrome. Ann Rheum Dis. 1981; 40(3):281-5. PMC: 1000763. DOI: 10.1136/ard.40.3.281. View

Dequeker J, Jamar R, Walravens M . HLA-B27, arthritis and Yersinia enterocolitica infection. J Rheumatol. 1980; 7(5):706-10. View

10.

Rouviere-Yaniv J, Yaniv M, Germond J . E. coli DNA binding protein HU forms nucleosomelike structure with circular double-stranded DNA. Cell. 1979; 17(2):265-74. DOI: 10.1016/0092-8674(79)90152-1. View

11.

Towbin H, Staehelin T, Gordon J . Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979; 76(9):4350-4. PMC: 411572. DOI: 10.1073/pnas.76.9.4350. View

12.

Geider K . Interaction of DNA with DNA-binding proteins: protein exchange and complex stability. Eur J Biochem. 1978; 87(3):617-22. DOI: 10.1111/j.1432-1033.1978.tb12414.x. View

13.

Varshavsky A, Nedospasov S, Bakayev V, Bakayeva T, Georgiev G . Histone-like proteins in the purified Escherichia coli deoxyribonucleoprotein. Nucleic Acids Res. 1977; 4(8):2725-45. PMC: 342604. DOI: 10.1093/nar/4.8.2725. View

14.

Brackertz D, Mitchell G, Mackay I . Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum. 1977; 20(3):841-50. DOI: 10.1002/art.1780200314. View

15.

Hollister J, Mannik M . Antigen retention in joint tissues in antigen-induced synovitis. Clin Exp Immunol. 1974; 16(4):615-27. PMC: 1554000. View

16.

McCONAHEY P, Dixon F . A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966; 29(2):185-9. DOI: 10.1159/000229699. View

17.

Cooke T, Hurd E, ZIFF M, Jasin H . The pathogenesis of chronic inflammation in experimental antigen-induced arthritis. II. Preferential localization of antigen-antibody complexes to collagenous tissues. J Exp Med. 1972; 135(2):323-38. PMC: 2180529. DOI: 10.1084/jem.135.2.323. View

18.

Cooke T, Jasin H . The pathogenesis of chronic inflammation in experimental antigen-induced arthritis. I. The role of antigen on the local immune response. Arthritis Rheum. 1972; 15(4):327-37. DOI: 10.1002/art.1780150402. View

19.

Vogt A, Bockhorn H, KOZIMA K, Sasaki M . Electron microscopic localization of the nephrotoxic antibody in the glomeruli of the rat after intravenous application of purified nephritogenic antibody-ferritin conjugates. J Exp Med. 1968; 127(5):867-78. PMC: 2138491. DOI: 10.1084/jem.127.5.867. View

20.

Griffiss J . Bactericidal activity of meningococcal antisera. Blocking by IgA of lytic antibody in human convalescent sera. J Immunol. 1975; 114(6):1779-84. View