Variation in the Susceptibility of Strains of Staphylococcus Aureus to Oxacillin, Cephalothin, and Gentamicin

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1976 Oct 1

PMID 984804

Citations 32

Authors

C G Mayhall

G Medoff

J J Marr

Affiliations

Soon will be listed here.

Abstract

Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated us to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.

Citing Articles

Antibiotic tolerance among clinical isolates: mechanisms, detection, prevalence, and significance.

Deventer A, Stevens C, Stewart A, Hobbs J Clin Microbiol Rev. 2024; 37(4):e0010624.

PMID: 39364999 PMC: 11629620. DOI: 10.1128/cmr.00106-24.

Bacterial persisters: molecular mechanisms and therapeutic development.

Niu H, Gu J, Zhang Y Signal Transduct Target Ther. 2024; 9(1):174.

PMID: 39013893 PMC: 11252167. DOI: 10.1038/s41392-024-01866-5.

Clinical Mutations That Partially Activate the Stringent Response Confer Multidrug Tolerance in .

Bryson D, Hettle A, Boraston A, Hobbs J Antimicrob Agents Chemother. 2019; 64(3).

PMID: 31871080 PMC: 7038295. DOI: 10.1128/AAC.02103-19.

Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective.

Overstreet D, McLaren A, Calara F, Vernon B, McLemore R Clin Orthop Relat Res. 2014; 473(1):337-47.

PMID: 25227556 PMC: 4390953. DOI: 10.1007/s11999-014-3935-9.

Staphylococcus aureus persisters tolerant to bactericidal antibiotics.

Lechner S, Lewis K, Bertram R J Mol Microbiol Biotechnol. 2012; 22(4):235-44.

PMID: 22986269 PMC: 3518770. DOI: 10.1159/000342449.

References

ERIKSEN K, Erichsen I . RESISTANCE TO METHICILLIN, ISOXAZOLYL PENICILLINS, AND CEPHALOTHIN IN STAPHYLOCOCCUS AUREUS. Acta Pathol Microbiol Scand. 1964; 62:255-75. DOI: 10.1111/apm.1964.62.2.255. View

GUNNISON J, FRAHER M, JAWETZ E . PERSISTENCE OF STAPHYLOCOCCUS AUREUS IN PENICILLIN IN VITRO. J Gen Microbiol. 1964; 35:335-49. DOI: 10.1099/00221287-35-2-335. View

Barber M . NATURALLY OCCURING METHICILLIN-RESISTANT STAPHYLOCOCCI. J Gen Microbiol. 1964; 35:183-90. DOI: 10.1099/00221287-35-2-183. View

Sutherland R, Rolinson G . CHARACTERISTICS OF METHICILLIN-RESISTANT STAPHYLOCOCCI. J Bacteriol. 1964; 87:887-99. PMC: 277108. DOI: 10.1128/jb.87.4.887-899.1964. View

BAUER A, KIRBY W, SHERRIS J, Turck M . Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966; 45(4):493-6. View

Greenwood D . Mucopeptide hydrolases and bacterial "persisters". Lancet. 1972; 2(7775):465-6. DOI: 10.1016/s0140-6736(72)91858-2. View

Sande M, Johnson M . Antimicrobial therapy of experimental endocarditis caused by Staphylococcus aureus. J Infect Dis. 1975; 131(4):367-75. DOI: 10.1093/infdis/131.4.367. View

Thornsberry C, Caruthers J, Baker C . Effect of temperature on the in vitro susceptibility of Staphylococcus aureus to penicillinase-resistant penicillins. Antimicrob Agents Chemother. 1973; 4(3):263-9. PMC: 444539. DOI: 10.1128/AAC.4.3.263. View

Hartmann R, Holtje J, Schwarz U . Targets of penicillin action in Escherichia coli. Nature. 1972; 235(5339):426-9. DOI: 10.1038/235426a0. View

10.

BEST G, BEST N, Koval A . Evidence for participation of autolysins in bactericidal action of oxacillin on Staphylococcus aureus. Antimicrob Agents Chemother. 1974; 6(6):825-30. PMC: 444744. DOI: 10.1128/AAC.6.6.825. View

11.

Watanakunakorm C, Glotzbecker C . Enhancement of the effects of anti-staphylococcal antibiotics by aminoglycosides. Antimicrob Agents Chemother. 1974; 6(6):802-6. PMC: 444739. DOI: 10.1128/AAC.6.6.802. View

12.

Watanakunakorn C, Tan J, Phair J . Some salient features of Staphylococcus aureus endocarditis. Am J Med. 1973; 54(4):473-81. DOI: 10.1016/0002-9343(73)90043-0. View

13.

BEST G, Koval A, BEST N . Susceptibility of clinical isolates of Staphylococcus aureus to killing by oxacillin. Can J Microbiol. 1975; 21(11):1692-7. DOI: 10.1139/m75-248. View

14.

Barrett F, McGehee Jr R, FINLAND M . Methicillin-resistant Staphylococcus aureus at Boston City Hospital. Bacteriologic and epidemiologic observations. N Engl J Med. 1968; 279(9):441-8. DOI: 10.1056/NEJM196808292790901. View