Activities of Gatifloxacin Compared to Those of Seven Other Agents Against Anaerobic Organisms

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1998 Sep 16

PMID 9736586

Citations 25

Authors

L M Ednie

M R Jacobs

P C Appelbaum

Affiliations

Soon will be listed here.

Abstract

The agar dilution MIC was used to compare activities of gatifloxacin with those of ciprofloxacin, sparfloxacin, trovafloxacin, ampicillin, ampicillin-sulbactam, clindamycin, and metronidazole against 351 anaerobes. Overall MICs at which 50% of the isolates are inhibited and MICs at which 90% of the isolates are inhibited (in micrograms per milliliter) were as follows: gatifloxacin, 0.5 and 4; ciprofloxacin, 2 and 32; sparfloxacin, 2 and 8; trovafloxacin, 1 and 4; ampicillin, 1 and 64; ampicillin-sulbactam, 0.5 and 4; clindamycin, 0.125 and 8; and metronidazole, 1 and >16, respectively. Gatifloxacin MICs were similar to those of trovafloxacin in all organism groups.

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References

Appelbaum P, Spangler S, Jacobs M . Evaluation of two methods for rapid testing for beta-lactamase production in Bacteroides and Fusobacterium. Eur J Clin Microbiol Infect Dis. 1990; 9(1):47-50. DOI: 10.1007/BF01969535. View

Bauernfeind A . Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin. J Antimicrob Chemother. 1998; 40(5):639-51. DOI: 10.1093/jac/40.5.639. View

Appelbaum P, Philippon A, Jacobs M, Spangler S, Gutmann L . Characterization of beta-lactamases from non-Bacteroides fragilis group Bacteroides spp. belonging to seven species and their role in beta-lactam resistance. Antimicrob Agents Chemother. 1990; 34(11):2169-76. PMC: 172019. DOI: 10.1128/AAC.34.11.2169. View

Barry A, Fuchs P . In vitro activities of sparfloxacin, tosufloxacin, ciprofloxacin, and fleroxacin. Antimicrob Agents Chemother. 1991; 35(5):955-60. PMC: 245135. DOI: 10.1128/AAC.35.5.955. View

Goldstein E, Citron D . Comparative activity of ciprofloxacin, ofloxacin, sparfloxacin, temafloxacin, CI-960, CI-990, and WIN 57273 against anaerobic bacteria. Antimicrob Agents Chemother. 1992; 36(5):1158-62. PMC: 188857. DOI: 10.1128/AAC.36.5.1158. View

Hosaka M, Yasue T, Fukuda H, Tomizawa H, Aoyama H, Hirai K . In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone. Antimicrob Agents Chemother. 1992; 36(10):2108-17. PMC: 245464. DOI: 10.1128/AAC.36.10.2108. View

Bauernfeind A . Comparative in-vitro activities of the new quinolone, Bay y 3118, and ciprofloxacin, sparfloxacin, tosufloxacin, CI-960 and CI-990. J Antimicrob Chemother. 1993; 31(4):505-22. DOI: 10.1093/jac/31.4.505. View

Barry A, Fuchs P, Citron D, Allen S, Wexler H . Methods for testing the susceptibility of anaerobic bacteria to two fluoroquinolone compounds, PD 131628 and clinafloxacin. J Antimicrob Chemother. 1993; 31(6):893-900. DOI: 10.1093/jac/31.6.893. View

Appelbaum P, Spangler S, Jacobs M . Susceptibility of 539 gram-positive and gram-negative anaerobes to new agents, including RP59500, biapenem, trospectomycin and piperacillin/tazobactam. J Antimicrob Chemother. 1993; 32(2):223-31. DOI: 10.1093/jac/32.2.223. View

10.

Appelbaum P, Spangler S, Pankuch G, Philippon A, Jacobs M, Shiman R . Characterization of a beta-lactamase from Clostridium clostridioforme. J Antimicrob Chemother. 1994; 33(1):33-40. DOI: 10.1093/jac/33.1.33. View

11.

Wakabayashi E, Mitsuhashi S . In vitro antibacterial activity of AM-1155, a novel 6-fluoro-8-methoxy quinolone. Antimicrob Agents Chemother. 1994; 38(3):594-601. PMC: 284503. DOI: 10.1128/AAC.38.3.594. View

12.

Spangler S, Jacobs M, Appelbaum P . Activity of CP 99,219 compared with those of ciprofloxacin, grepafloxacin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam against 489 anaerobes. Antimicrob Agents Chemother. 1994; 38(10):2471-6. PMC: 284766. DOI: 10.1128/AAC.38.10.2471. View

13.

Hosaka M, Kinoshita S, Toyama A, Otsuki M, Nishino T . Antibacterial properties of AM-1155, a new 8-methoxy quinolone. J Antimicrob Chemother. 1995; 36(2):293-301. DOI: 10.1093/jac/36.2.293. View

14.

Nakashima M, Uematsu T, Kosuge K, Kusajima H, Ooie T, Masuda Y . Single- and multiple-dose pharmacokinetics of AM-1155, a new 6-fluoro-8-methoxy quinolone, in humans. Antimicrob Agents Chemother. 1995; 39(12):2635-40. PMC: 163003. DOI: 10.1128/AAC.39.12.2635. View

15.

Wexler H, Molitoris E, Molitoris D, Finegold S . In vitro activities of trovafloxacin against 557 strains of anaerobic bacteria. Antimicrob Agents Chemother. 1996; 40(9):2232-5. PMC: 163509. DOI: 10.1128/AAC.40.9.2232. View

16.

Spangler S, Jacobs M, Appelbaum P . Bactericidal activity of DU-6859a compared to activities of three quinolones, three beta-lactams, clindamycin, and metronidazole against anaerobes as determined by time-kill methodology. Antimicrob Agents Chemother. 1997; 41(4):847-9. PMC: 163808. DOI: 10.1128/AAC.41.4.847. View

17.

Wise R, Brenwald N, Andrews J, Boswell F . The activity of the methylpiperazinyl fluoroquinolone CG 5501: a comparison with other fluoroquinolones. J Antimicrob Chemother. 1997; 39(4):447-52. DOI: 10.1093/jac/39.4.447. View

18.

Kato N, Kato H, Tanaka-Bandoh K, Watanabe K, Ueno K . Comparative in-vitro and in-vivo activity of AM-1155 against anaerobic bacteria. J Antimicrob Chemother. 1998; 40(5):631-7. DOI: 10.1093/jac/40.5.631. View

19.

Appelbaum P, Spangler S, Jacobs M . Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28.... Antimicrob Agents Chemother. 1990; 34(8):1546-50. PMC: 171870. DOI: 10.1128/AAC.34.8.1546. View