Beta Interferon is Produced by Chlamydia Trachomatis-infected Fibroblast-like Synoviocytes and Inhibits Gamma Interferon-induced HLA-DR Expression

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1998 Aug 26

PMID 9712805

Citations 12

Authors

J Rodel

A Groh

H Vogelsang

M Lehmann

M Hartmann

E Straube

Affiliations

Soon will be listed here.

Abstract

Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-beta). Chlamydial infection inhibited IFN-gamma-induced expression of HLA-DR antigen in the cells. Addition of IFN-beta antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-beta.

Citing Articles

When Bacteria and Viruses Collide: A Tale of and Sexually Transmitted Viruses.

Ghasemian E, Harding-Esch E, Mabey D, Holland M Viruses. 2023; 15(9).

PMID: 37766360 PMC: 10536055. DOI: 10.3390/v15091954.

Modelling of Infection in the Etiopathogenesis of Male Infertility and Reactive Arthritis.

Filardo S, Di Pietro M, Diaco F, Sessa R Front Cell Infect Microbiol. 2022; 12:840802.

PMID: 35174109 PMC: 8841781. DOI: 10.3389/fcimb.2022.840802.

Chlamydia trachomatis: the Persistent Pathogen.

Witkin S, Minis E, Athanasiou A, Leizer J, Linhares I Clin Vaccine Immunol. 2017; 24(10).

PMID: 28835360 PMC: 5629669. DOI: 10.1128/CVI.00203-17.

Analyses of the pathways involved in early- and late-phase induction of IFN-beta during C. muridarum infection of oviduct epithelial cells.

Hu S, Hosey K, Derbigny W PLoS One. 2015; 10(3):e0119235.

PMID: 25798928 PMC: 4370658. DOI: 10.1371/journal.pone.0119235.

Chlamydia muridarum infection associated host MicroRNAs in the murine genital tract and contribution to generation of host immune response.

Gupta R, Arkatkar T, Yu J, Wali S, Haskins W, Chambers J Am J Reprod Immunol. 2014; 73(2):126-40.

PMID: 24976530 PMC: 4357020. DOI: 10.1111/aji.12281.

References

Firestein G, Zvaifler N . Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. I. A cytofluorographic study of monocyte differentiation antigens and class II antigens and their regulation by gamma-interferon. Arthritis Rheum. 1987; 30(8):857-63. DOI: 10.1002/art.1780300803. View

Burmester G, Jahn B, Rohwer P, Zacher J, Winchester R, Kalden J . Differential expression of Ia antigens by rheumatoid synovial lining cells. J Clin Invest. 1987; 80(3):595-604. PMC: 442280. DOI: 10.1172/JCI113111. View

Hughes R, Hyder E, TREHARNE J, Keat A . Intra-articular chlamydial antigen and inflammatory arthritis. Q J Med. 1991; 80(291):575-88. View

Hammer M, Nettelnbreker E, Hopf S, Schmitz E, Porschke K, Zeidler H . Chlamydial rRNA in the joints of patients with Chlamydia-induced arthritis and undifferentiated arthritis. Clin Exp Rheumatol. 1992; 10(1):63-6. View

Simon A, Seipelt E, Wu P, Wenzel B, Braun J, Sieper J . Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset. Clin Exp Immunol. 1993; 94(1):122-6. PMC: 1534378. DOI: 10.1111/j.1365-2249.1993.tb05988.x. View

Hassell A, Reynolds D, Deacon M, Gaston J, PEARCE J . Identification of T-cell stimulatory antigens of Chlamydia trachomatis using synovial fluid-derived T-cell clones. Immunology. 1993; 79(4):513-9. PMC: 1421918. View

Paguirigan A, Byrne G, Becht S, Carlin J . Cytokine-mediated indoleamine 2,3-dioxygenase induction in response to Chlamydia infection in human macrophage cultures. Infect Immun. 1994; 62(4):1131-6. PMC: 186239. DOI: 10.1128/iai.62.4.1131-1136.1994. View

Beatty W, Belanger T, Desai A, Morrison R, Byrne G . Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence. Infect Immun. 1994; 62(9):3705-11. PMC: 303021. DOI: 10.1128/iai.62.9.3705-3711.1994. View

Boots A, Rijnders A . Antigen-presenting capacity of rheumatoid synovial fibroblasts. Immunology. 1994; 82(2):268-74. PMC: 1414827. View

10.

Malone D, Dolan P, Brown R, Kalayoglu M, Arend R, Byrne G . Interferon gamma induced production of indoleamine 2,3 dioxygenase in cultured human synovial cells. J Rheumatol. 1994; 21(6):1011-9. View

11.

Beatty W, Morrison R, Byrne G . Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev. 1994; 58(4):686-99. PMC: 372987. DOI: 10.1128/mr.58.4.686-699.1994. View

12.

Sedmak D, Chaiwiriyakul S, Knight D, Waldmann W . The role of interferon beta in human cytomegalovirus-mediated inhibition of HLA DR induction on endothelial cells. Arch Virol. 1995; 140(1):111-26. DOI: 10.1007/BF01309727. View

13.

Nanagara R, Li F, Beutler A, Hudson A, Schumacher Jr H . Alteration of Chlamydia trachomatis biologic behavior in synovial membranes. Suppression of surface antigen production in reactive arthritis and Reiter's syndrome. Arthritis Rheum. 1995; 38(10):1410-7. DOI: 10.1002/art.1780381008. View

14.

Lu H, Riley J, Babcock G, Huston M, Stark G, Boss J . Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma. J Exp Med. 1995; 182(5):1517-25. PMC: 2192209. DOI: 10.1084/jem.182.5.1517. View

15.

Beutler A, Schumacher Jr H, Whittum-Hudson J, Salameh W, Hudson A . Case report: in situ hybridization for detection of inapparent infection with Chlamydia trachomatis in synovial tissue of a patient with Reiter's syndrome. Am J Med Sci. 1995; 310(5):206-13. DOI: 10.1097/00000441-199511000-00006. View

16.

Huppertz H, Heesemann J . Experimental Yersinia infection of human synovial cells: persistence of live bacteria and generation of bacterial antigen deposits including "ghosts," nucleic acid-free bacterial rods. Infect Immun. 1996; 64(4):1484-7. PMC: 173950. DOI: 10.1128/iai.64.4.1484-1487.1996. View

17.

Heinzen R, Scidmore M, Rockey D, Hackstadt T . Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect Immun. 1996; 64(3):796-809. PMC: 173840. DOI: 10.1128/iai.64.3.796-809.1996. View

18.

Rodel J, Straube E, Lungershausen W, Roth A, Groh A . Primary cultivation of human synovial cells from nonrheumatic synovial tissue and fluid. Exp Toxicol Pathol. 1996; 48(4):243-7. DOI: 10.1016/S0940-2993(96)80006-6. View

19.

Boehm U, Klamp T, Groot M, Howard J . Cellular responses to interferon-gamma. Annu Rev Immunol. 1997; 15:749-95. DOI: 10.1146/annurev.immunol.15.1.749. View

20.

Armstrong J . Cytopathic effect inhibition assay for interferon: microculture plate assay. Methods Enzymol. 1981; 78(Pt A):381-7. DOI: 10.1016/0076-6879(81)78145-x. View