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Enteroaggregative Escherichia Coli

Overview
Journal Emerg Infect Dis
Specialty Infectious Diseases
Date 1998 Jun 11
PMID 9621195
Citations 66
Authors
J P Nataro
T Steiner
R L Guerrant
Affiliations
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Abstract

Enteroaggregative Escherichia coli (EAEC), an increasingly recognized cause of diarrhea in children in developing countries, has been particularly associated with persistent diarrhea (more than 14 days), a major cause of illness and death. Recent outbreaks implicate EAEC as a cause of foodborne illness in industrialized countries. The pathogenesis of EAEC infection is not well understood, but a model can be proposed in which EAEC adhere to the intestinal mucosa and elaborate enterotoxins and cytotoxins, which result in secretory diarrhea and mucosal damage. EAEC's ability to stimulate the release of inflammatory mediators may also play a role in intestinal illness.

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References
1.
Wanke C, Cronan S, Goss C, Chadee K, Guerrant R . Characterization of binding of Escherichia coli strains which are enteropathogens to small-bowel mucin. Infect Immun. 1990; 58(3):794-800. PMC: 258535. DOI: 10.1128/iai.58.3.794-800.1990. View
2.
Baldwin T, Knutton S, Sellers L, Hernandez H, Aitken A, Williams P . Enteroaggregative Escherichia coli strains secrete a heat-labile toxin antigenically related to E. coli hemolysin. Infect Immun. 1992; 60(5):2092-5. PMC: 257119. DOI: 10.1128/iai.60.5.2092-2095.1992. View
3.
Vial P, Mathewson J, DuPont H, Guers L, Levine M . Comparison of two assay methods for patterns of adherence to HEp-2 cells of Escherichia coli from patients with diarrhea. J Clin Microbiol. 1990; 28(5):882-5. PMC: 267829. DOI: 10.1128/jcm.28.5.882-885.1990. View
4.
Schorling J, McAuliffe J, de Souza M, Guerrant R . Malnutrition is associated with increased diarrhoea incidence and duration among children in an urban Brazilian slum. Int J Epidemiol. 1990; 19(3):728-35. DOI: 10.1093/ije/19.3.728. View
5.
Cravioto A, Tello A, Navarro A, Ruiz J, Villafan H, Uribe F . Association of Escherichia coli HEp-2 adherence patterns with type and duration of diarrhoea. Lancet. 1991; 337(8736):262-4. DOI: 10.1016/0140-6736(91)90868-p. View