Enteroaggregative Escherichia Coli Strains Secrete a Heat-labile Toxin Antigenically Related to E. Coli Hemolysin

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1992 May 1

PMID 1563799

Citations 19

Authors

T J Baldwin

S Knutton

L Sellers

H A Hernandez

A Aitken

P H Williams

Affiliations

Soon will be listed here.

Abstract

A protein toxin of approximately 120,000 Da secreted by nonhemolytic enteroaggregative Escherichia coli strains cross-reacted in Western blots (immunoblots) with antibodies raised against the C-terminal region of E. coli hemolysin. Treatment of HEp-2 cells with enteroaggregative E. coli or culture supernatants caused elevation of intracellular calcium and stimulated calcium-dependent protein phosphorylation.

Citing Articles

Enteroaggregative and cell-detaching Escherichia coli strains among Polish children with and without diarrhea.

Sobieszczanska B, Osek J Folia Microbiol (Praha). 2004; 48(6):823-8.

PMID: 15058198 DOI: 10.1007/BF02931520.

Hemolysin-positive enteroaggregative and cell-detaching Escherichia coli strains cause oncosis of human monocyte-derived macrophages and apoptosis of murine J774 cells.

Fernandez-Prada C, Tall B, Elliott S, Hoover D, Nataro J, Venkatesan M Infect Immun. 1998; 66(8):3918-24.

PMID: 9673280 PMC: 108451. DOI: 10.1128/IAI.66.8.3918-3924.1998.

Pet, an autotransporter enterotoxin from enteroaggregative Escherichia coli.

Eslava C, Navarro-Garcia F, Czeczulin J, Henderson I, Cravioto A, Nataro J Infect Immun. 1998; 66(7):3155-63.

PMID: 9632580 PMC: 108327. DOI: 10.1128/IAI.66.7.3155-3163.1998.

In vitro effects of a high-molecular-weight heat-labile enterotoxin from enteroaggregative Escherichia coli.

Navarro-Garcia F, Eslava C, Villaseca J, Lopez-Revilla R, Czeczulin J, Srinivas S Infect Immun. 1998; 66(7):3149-54.

PMID: 9632579 PMC: 108326. DOI: 10.1128/IAI.66.7.3149-3154.1998.

Enteroaggregative Escherichia coli.

Nataro J, Steiner T, Guerrant R Emerg Infect Dis. 1998; 4(2):251-61.

PMID: 9621195 PMC: 2640136. DOI: 10.3201/eid0402.980212.

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