A One Health Perspective for Defining and Deciphering Pathogenic Potential in Multiple Hosts

Overview

Journal Comp Med

Specialty General Medicine

Date 2021 Jan 9

PMID 33419487

Citations 10

Authors

Alexis Garcia

James G Fox

Affiliations

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Abstract

is one of the most common species of bacteria colonizing humans and animals. The singularity of 's genus and species underestimates its multifaceted nature, which is represented by different strains, each with different combinations of distinct virulence factors. In fact, several pathotypes, or hybrid strains, may be associated with both subclinical infection and a range of clinical conditions, including enteric, urinary, and systemic infections. may also express DNA-damaging toxins that could impact cancer development. This review summarizes the different pathotypes in the context of their history, hosts, clinical signs, epidemiology, and control. The pathotypic characterization of in the context of disease in different animals, including humans, provides comparative and One Health perspectives that will guide future clinical and research investigations of infections.

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