Evidence for HSP70-like Protein in the RBC Membrane of the Hereditarily Anemic Belgrade Laboratory (b/b) Rat

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 1998 Apr 18

PMID 9546590

Citations 1

Authors

J Zaric

V GLISIN

Z Popovic

Affiliations

Soon will be listed here.

Abstract

We have demonstrated that in normal and b/b rat red blood cells (RBCs) hsp70-like protein (heat shock protein 70-like) is localized in the cytosol and it is exported via exosomes during in vivo reticulocytes maturation. As we have presumed, in the mutant (b/b) rat, hsp70-like protein transfers from cytosol to the RBC membrane. In the normal rat RBCs this happens when those cells are submitted to heat stress conditions. Our study indicates that the presence of hsp70-like protein in the b/b rat RBC plasma membrane is consistent with a primary defect and is not a consequence of life long stress, i.e. hypoxia.

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