Molecular Chaperones: Proteins Essential for the Biogenesis of Some Macromolecular Structures

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 1989 Aug 1

PMID 2572080

Citations 97

Authors

R J Ellis

S M Hemmingsen

Affiliations

Soon will be listed here.

Abstract

Many polypeptides can self-assemble into functional structures while others assemble only in the presence of additional proteins (molecular chaperones) which are not components of the final structure. We discuss here the effect that the recognition of the essential roles played by these proteins in assembly processes may have on the principle of spontaneous self-assembly.

Citing Articles

Molecular Chaperones as Therapeutic Target: Hallmark of Neurodegenerative Disorders.

Sharma A, Shah O, Sharma L, Gulati M, Behl T, Khalid A Mol Neurobiol. 2023; 61(7):4750-4767.

PMID: 38127187 DOI: 10.1007/s12035-023-03846-2.

Chaperone-assisted E3 ligase CHIP: A double agent in cancer.

Kumar S, Basu M, Ghosh M Genes Dis. 2022; 9(6):1521-1555.

PMID: 36157498 PMC: 9485218. DOI: 10.1016/j.gendis.2021.08.003.

Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases.

Upadhyay A Acta Pharm Sin B. 2021; 11(10):2995-3014.

PMID: 34729300 PMC: 8546668. DOI: 10.1016/j.apsb.2021.01.006.

Cytosolic protein quality control machinery: Interactions of Hsp70 with a network of co-chaperones and substrates.

Karunanayake C, Page R Exp Biol Med (Maywood). 2021; 246(12):1419-1434.

PMID: 33730888 PMC: 8243209. DOI: 10.1177/1535370221999812.

Assistance for Folding of Disease-Causing Plasma Membrane Proteins.

Juarez-Navarro K, Ayala-Garcia V, Ruiz-Baca E, Meneses-Morales I, Rios-Banuelos J, Lopez-Rodriguez A Biomolecules. 2020; 10(5).

PMID: 32392767 PMC: 7277483. DOI: 10.3390/biom10050728.